Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …

BACKGROUND Uterine leiomyoma (also known as fibroid or myoma) is the most common
benign tumor of the uterus found in women of reproductive age. It is not usually fatal but can …

Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

The extracellular matrix (ECM) proteoglycan, versican increases along with other ECM
versican binding molecules such as hyaluronan, tumor necrosis factor stimulated gene-6 …

Intervertebral disc (IVD) degeneration (IDD) is a pathological process that commonly occurs
throughout the human life span and is a major cause of lower back pain. Better elucidation …

Hyaluronan and versican are extracellular matrix (ECM) components that are enriched in the
provisional matrices that form during the early stages of development and disease. These …

The development of cancer immunotherapy, particularly immune checkpoint blockade
therapy, has made major breakthroughs in the therapy of cancers. However, less than one …

Group 2 innate lymphoid cells (ILC2s) are enriched in mucosal tissues (eg, lung) and
respond to epithelial cell–derived cytokines initiating type 2 inflammation. During …

Versican is an extracellular matrix proteoglycan with key roles in multiple facets of cancer
development, ranging from proliferative signaling, evasion of growth-suppressor pathways …

During inflammation, leukocytes influx into lung compartments and interact with extracellular
matrix (ECM). Two ECM components, versican and hyaluronan, increase in a range of lung …