Norovirus antivirals: Where are we now?
NE Netzler, D Enosi Tuipulotu… - Medicinal research …, 2019 - Wiley Online Library
Human noroviruses inflict a significant health burden on society and are responsible for
approximately 699 million infections and over 200 000 estimated deaths worldwide each …
approximately 699 million infections and over 200 000 estimated deaths worldwide each …
Calicivirus RNA-dependent RNA polymerases: evolution, structure, protein dynamics, and function
The Caliciviridae are viruses with a positive-sense, single-stranded RNA genome that is
packaged into an icosahedral, environmentally stable protein capsid. The family contains …
packaged into an icosahedral, environmentally stable protein capsid. The family contains …
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase
AP Bertolin, F Weissmann, J Zeng, V Posse… - Biochemical …, 2021 - portlandpress.com
The coronavirus disease 2019 (COVID-19) global pandemic has turned into the largest
public health and economic crisis in recent history impacting virtually all sectors of society …
public health and economic crisis in recent history impacting virtually all sectors of society …
Identification and characterization of Zika virus NS5 RNA-dependent RNA polymerase inhibitors
Y Lin, H Zhang, W Song, S Si, Y Han, J Jiang - International journal of …, 2019 - Elsevier
The current outbreak of Zika virus (ZIKV) is the impetus for novel, safe and efficacious anti-
ZIKV agents. ZIKV non-structural protein 5 RNA-dependent RNA polymerase (RdRp) is …
ZIKV agents. ZIKV non-structural protein 5 RNA-dependent RNA polymerase (RdRp) is …
Current and future antiviral strategies to tackle gastrointestinal viral infections
N Santos-Ferreira, J Van Dycke, J Neyts… - Microorganisms, 2021 - mdpi.com
Acute gastroenteritis caused by virus has a major impact on public health worldwide in terms
of morbidity, mortality, and economic burden. The main culprits are rotaviruses, noroviruses …
of morbidity, mortality, and economic burden. The main culprits are rotaviruses, noroviruses …
Targeting the viral polymerase of diarrhea-causing viruses as a strategy to develop a single broad-spectrum antiviral therapy
Viral gastroenteritis is an important cause of morbidity and mortality worldwide, being
particularly severe for children under the age of five. The most common viral agents of …
particularly severe for children under the age of five. The most common viral agents of …
Potential therapeutic agents for feline calicivirus infection
Feline calicivirus (FCV) is a major cause of upper respiratory tract disease in cats, with
widespread distribution in the feline population. Recently, virulent systemic diseases caused …
widespread distribution in the feline population. Recently, virulent systemic diseases caused …
TLR7 agonists display potent antiviral effects against norovirus infection via innate stimulation
D Enosi Tuipulotu, NE Netzler, JH Lun… - Antimicrobial agents …, 2018 - Am Soc Microbiol
Norovirus infections are a significant health and economic burden globally, accounting for
hundreds of millions of cases of acute gastroenteritis every year. In the absence of an …
hundreds of millions of cases of acute gastroenteritis every year. In the absence of an …
In silico screening for human norovirus antivirals reveals a novel non-nucleoside inhibitor of the viral polymerase
S Ferla, NE Netzler, S Ferla, S Veronese… - Scientific reports, 2018 - nature.com
Human norovirus causes approximately 219,000 deaths annually, yet there are currently no
antivirals available. A virtual screening of commercially available drug-like compounds …
antivirals available. A virtual screening of commercially available drug-like compounds …
Predicting new anti-norovirus inhibitor with the help of machine learning algorithms and molecular dynamics simulation–based model
O Ebenezer, N Damoyi, M Shapi - Frontiers in chemistry, 2021 - frontiersin.org
Hepatitis C virus (HCV) inhibitors are essential in the treatment of human norovirus
(HuNoV). This study aimed to map out HCV NS5B RNA-dependent RNA polymerase …
(HuNoV). This study aimed to map out HCV NS5B RNA-dependent RNA polymerase …