Disruption of axonal transport in neurodegeneration
SH Berth, TE Lloyd - The Journal of Clinical Investigation, 2023 - Am Soc Clin Investig
Neurons are markedly compartmentalized, which makes them reliant on axonal transport to
maintain their health. Axonal transport is important for anterograde delivery of newly …
maintain their health. Axonal transport is important for anterograde delivery of newly …
Molecular pathophysiological mechanisms in Huntington's disease
A Jurcau - Biomedicines, 2022 - mdpi.com
Huntington's disease is an inherited neurodegenerative disease described 150 years ago
by George Huntington. The genetic defect was identified in 1993 to be an expanded CAG …
by George Huntington. The genetic defect was identified in 1993 to be an expanded CAG …
Huntingtin and the Synapse
Huntington disease (HD) is a monogenic disease that results in a combination of motor,
psychiatric and cognitive symptoms. HD is caused by a CAG trinucleotide repeat expansion …
psychiatric and cognitive symptoms. HD is caused by a CAG trinucleotide repeat expansion …
LSD1/PRMT6-targeting gene therapy to attenuate androgen receptor toxic gain-of-function ameliorates spinobulbar muscular atrophy phenotypes in flies and mice
R Prakasam, A Bonadiman, R Andreotti… - Nature …, 2023 - nature.com
Spinobulbar muscular atrophy (SBMA) is caused by CAG expansions in the androgen
receptor gene. Androgen binding to polyQ-expanded androgen receptor triggers SBMA …
receptor gene. Androgen binding to polyQ-expanded androgen receptor triggers SBMA …
Traffic signaling: new functions of huntingtin and axonal transport in neurological disease
H Vitet, V Brandt, F Saudou - Current Opinion in Neurobiology, 2020 - Elsevier
Highlights•Subtle changes in axonal transport can modulate protein accumulation at the
synapse.•The huntingtin mutation underlying Huntington's disease disrupts axonal …
synapse.•The huntingtin mutation underlying Huntington's disease disrupts axonal …
Huntingtin recruits KIF1A to transport synaptic vesicle precursors along the mouse axon to support synaptic transmission and motor skill learning
H Vitet, J Bruyère, H Xu, C Séris, J Brocard, YS Abada… - Elife, 2023 - elifesciences.org
Neurotransmitters are released at synapses by synaptic vesicles (SVs), which originate from
SV precursors (SVPs) that have traveled along the axon. Because each synapse maintains …
SV precursors (SVPs) that have traveled along the axon. Because each synapse maintains …
Critical roles of protein arginine methylation in the central nervous system
K Chang, D Gao, J Yan, L Lin, T Cui, S Lu - Molecular Neurobiology, 2023 - Springer
A remarkable post-transitional modification of both histones and non-histone proteins is
arginine methylation. Methylation of arginine residues is crucial for a wide range of cellular …
arginine methylation. Methylation of arginine residues is crucial for a wide range of cellular …
Understanding how kinesin motor proteins regulate postsynaptic function in neuron
The Kinesin superfamily proteins (KIFs) are major molecular motors that transport diverse
set of cargoes along microtubules to both the axon and dendrite of a neuron. Much of our …
set of cargoes along microtubules to both the axon and dendrite of a neuron. Much of our …
Interaction of huntingtin with PRMTs and its subsequent arginine methylation affects HTT solubility, phase transition behavior and neuronal toxicity
Huntington's disease (HD) is an incurable neurodegenerative disorder caused by a CAG
expansion in the huntingtin gene (HTT). Post-translational modifications of huntingtin protein …
expansion in the huntingtin gene (HTT). Post-translational modifications of huntingtin protein …
Drosophila melanogaster as a model to study autophagy in neurodegenerative diseases induced by proteinopathies
S Santarelli, C Londero, A Soldano… - Frontiers in …, 2023 - frontiersin.org
Proteinopathies are a large group of neurodegenerative diseases caused by both genetic
and sporadic mutations in particular genes which can lead to alterations of the protein …
and sporadic mutations in particular genes which can lead to alterations of the protein …