The disturbance of apoptosis molecular signaling pathways is involved in carcinogenesis.
BCL2 family of proteins is the hallmark of apoptosis regulation. In the last decade, new …

Purpose Many anticancer drugs induce apoptosis in malignant cells, and resistance to
apoptosis could lead to suboptimal or no therapeutic benefit. Two cytoplasmic proteins, B …

Cancer cells acquire disruptions in normal signal transduction pathways and homeostatic
mechanisms that would trigger apoptosis in normal cells. These abnormalities include …

Systemically applied agents to modulate the Fas/FasL system, eg, by stimulation of Fas on
activated leukocytes or tumor cells failed as strategies in immune therapy due to severe toxic …

Background ABT-737 is a pan-Bcl-2 inhibitor that has a wide range of single-agent activity
against acute lymphoblastic leukemia (ALL) cell lines and xenografts. A relationship …

Background: Overexpression of the antiapoptotic protein Bcl-2 causes apoptosis to stop and
conversely the increased expression of the proapoptotic protein Bax makes lymphoblasts …

The long-term outcome of allogeneic hematopoietic stem cell transplantation (HSCT) in
chemorefractory acute myeloid leukemia (AML) remains suboptimal because of a high …

A growing body of literature suggests that pharmaceutical contamination poses an
increasing risk to marine ecosystems. Paracetamol or acetaminophen is the most widely …

It has been suggested that leukemia is characterized by an impaired balance between the
proliferation of blood cells and their capacity to undergo apoptosis. The aim of this study was …

Background: BCL-2 is the most important anti-apoptotic regulator and Bax is a pro-apoptotic
protein. The status of these parameters or the ration of BCL-2 to BAX is important in …