An update on the mechanisms related to cell death and toxicity of doxorubicin and the protective role of nutrients
Doxorubicin (DOX), is a very effective chemotherapeutic agent against cancer whose clinical
use is limited by toxicity. Different strategies have been proposed to attenuate toxicity …
use is limited by toxicity. Different strategies have been proposed to attenuate toxicity …
[HTML][HTML] Apigenin ameliorates doxorubicin-induced renal injury via inhibition of oxidative stress and inflammation
Q Wu, W Li, J Zhao, W Sun, Q Yang, C Chen… - Biomedicine & …, 2021 - Elsevier
Background and objective Doxorubicin (DOX) is an anthracycline antitumor antibiotic widely
utilized in treating various tumors. Nevertheless, the toxicity of DOX toward normal cells …
utilized in treating various tumors. Nevertheless, the toxicity of DOX toward normal cells …
Mesenchymal stem cell therapy for doxorubicin-induced cardiomyopathy: potential mechanisms, governing factors, and implications of the heart stem cell debate
Over the past decades, researchers have reported several mechanisms for doxorubicin
(DOX)-induced cardiomyopathy, including oxidative stress, inflammation, and apoptosis …
(DOX)-induced cardiomyopathy, including oxidative stress, inflammation, and apoptosis …
Protective effect of morin on doxorubicin-induced hepatorenal toxicity in rats
Although Doxorubicin (DOX) is a widespread drug used in the treatment of cancer, its
clinical use is restricted due to its common side effects. In addition, administrating DOX with …
clinical use is restricted due to its common side effects. In addition, administrating DOX with …
[HTML][HTML] Protective effect of diosmin against doxorubicin-induced nephrotoxicity
Doxorubicin (Dox) is an anthracycline antibiotic that is primarily used for treating various
solid tumors including that of pulmonary, ovary, breast, uterine, cervix, and several blood …
solid tumors including that of pulmonary, ovary, breast, uterine, cervix, and several blood …
Protective mechanisms of atorvastatin against doxorubicin-induced hepato-renal toxicity
MA El-Moselhy, AAK El-Sheikh - Biomedicine & Pharmacotherapy, 2014 - Elsevier
To investigate the mechanisms by which the anticancer drug doxorubicin (DOX)-induced
hepato-renal damage could be prevented by the cholesterol-lowering statin, atorvastatin …
hepato-renal damage could be prevented by the cholesterol-lowering statin, atorvastatin …
Resveratrol may dose-dependently modulate nephrin and OTULIN levels in a doxorubicin-induced nephrotoxicity model
One of the most important side effects of Doxorubicin (DOX), a chemotherapeutic agent, is
nephrotoxicity. The purpose of this study is to determine whether different doses of natural …
nephrotoxicity. The purpose of this study is to determine whether different doses of natural …
[PDF][PDF] Protective effect of quercetin against oxidative stress-induced toxicity associated with doxorubicin and cyclophosphamide in rat kidney and liver tissue
Materials and Methods. Cyclophosphamide, 27 mg/kg, and doxorubicin, 1.8 mg/kg, were
administered to rats as intraperitoneal doses once every 3 weeks for a total of 10 weeks with …
administered to rats as intraperitoneal doses once every 3 weeks for a total of 10 weeks with …
Esculetin improves inflammation of the kidney via gene expression against doxorubicin-induced nephrotoxicity in rats: In vivo and in silico studies
Examining the preventive potential and underlying mechanisms of Esculetin (E) in mitigating
kidney damage induced by doxorubicin (DOX) in rats, this study also assessed the …
kidney damage induced by doxorubicin (DOX) in rats, this study also assessed the …
The protective effects of esculetin against Doxorubicin‐Induced hepatotoxicity in rats: Insights into the modulation of Caspase, FOXOs, and heat shock protein …
Doxorubicin (DOX) is an anthracycline antibiotic widely employed to treat carcinoma.
Nevertheless, severe cardiotoxic side effects restrict its clinical use. Esculetin, a natural …
Nevertheless, severe cardiotoxic side effects restrict its clinical use. Esculetin, a natural …