Human development requires intricate cell specification and communication pathways that
allow an embryo to generate and appropriately connect more than 200 different cell types …

Background & Aims Intraductal papillary mucinous neoplasms (IPMNs) are regarded as
precursors of pancreatic ductal adenocarcinomas (PDAs), but little is known about the …

Abstract Purpose of Review This article reviews the current literature on dietary
interventions, including time-restricted eating (TRE), intermittent fasting (IF), and fasting …

The Wnt signaling pathway plays important roles in embryonic development, homeostatic
processes, cell differentiation, cell polarity, cell proliferation, and cell migration via the β …

Post-translational modifications such as ubiquitination play important regulatory roles in
several biological processes in eukaryotes. This process could be reversed by …

Since the discovery of the ubiquitin proteasome system (UPS), the roles of ubiquitinating
and deubiquitinating enzymes (DUBs) have been widely elucidated. The ubiquitination of …

The tumor suppressor gene adenomatous polyposis coli (APC) is mutated in most colorectal
cancers (CRCs), resulting in constitutive Wnt activation. To understand the Wnt-activating …

Aberrant activation of the Wnt/β-catenin pathway is frequently found in various cancers, often
through mutations of downstream components. Inhibiting β-catenin signaling in tumors with …

The relative abundance of Wnt receptors plays a crucial role in controlling Wnt signaling in
tissue homeostasis and human disease. While the ubiquitin ligases that ubiquitylate Wnt …

Deubiquitylating enzymes (DUBs) maintain relative homeostasis of the cellular ubiquitome
by removing the post‐translational modification ubiquitin moiety from substrates. Numerous …