Effects of gut microbiota on immune responses and immunotherapy in colorectal cancer

X Hou, Z Zheng, J Wei, L Zhao - Frontiers in Immunology, 2022 - frontiersin.org
Accumulating evidence suggests that gut microbial dysbiosis is implicated in colorectal
cancer (CRC) initiation and progression through interaction with host immune system. Given …

[HTML][HTML] A fecal microRNA signature by small RNA sequencing accurately distinguishes colorectal cancers: results from a multicenter study

B Pardini, G Ferrero, S Tarallo, G Gallo, A Francavilla… - Gastroenterology, 2023 - Elsevier
Background & Aims Fecal tests currently used for colorectal cancer (CRC) screening show
limited accuracy in detecting early tumors or precancerous lesions. In this respect, we …

Colon cancer microbiome landscaping: differences in right-and left-sided colon cancer and a tumor microbiome-ileal microbiome association

B Kneis, S Wirtz, K Weber, A Denz, M Gittler… - International Journal of …, 2023 - mdpi.com
In the current era of precision oncology, it is widely acknowledged that CRC is a
heterogeneous disease entity. Tumor location (right-or left-sided colon cancer or rectal …

Luminal and tumor-associated gut microbiome features linked to precancerous lesions malignancy risk: a compositional approach

VA Romanov, IA Karasev, NS Klimenko, SI Koshechkin… - Cancers, 2022 - mdpi.com
Simple Summary Studies of gut microbiome in patients with colorectal cancer (CRC) have
shown strong alterations of its community structure. Identification of the early signs of …

Environmental insults and compensative responses: when microbiome meets cancer

S Nagpal, SS Mande - Discover Oncology, 2023 - Springer
Tumor microenvironment has recently been ascribed a new hallmark—the polymorphic
microbiome. Accumulating evidence regarding the tissue specific territories of tumor …

Mucosal Microbiota from Colorectal Cancer, Adenoma and Normal Epithelium Reveals the Imprint of Fusobacterium nucleatum in Cancerogenesis

O Palmieri, S Castellana, A Latiano, T Latiano… - Microorganisms, 2023 - mdpi.com
An increasing amount of evidence suggests the emerging role of the gut microbiota in the
development of colorectal cancer (CRC). This study aimed to elucidate the architecture of …

From colon wall to tumor niche: Unraveling the microbiome's role in colorectal cancer progression

G García Menéndez, L Sichel, MC López, Y Hernández… - Plos one, 2024 - journals.plos.org
Colorectal cancer (CRC) is influenced by perturbations in the colonic microbiota,
characterized by an imbalance favoring pathogenic bacteria over beneficial ones. This …

[HTML][HTML] Tumor-associated microbiome features of metastatic colorectal cancer and clinical implications

HJ An, MA Partha, HJ Lee, BT Lau, DS Pavlichin… - Frontiers in …, 2024 - frontiersin.org
Background Colon microbiome composition contributes to the pathogenesis of colorectal
cancer (CRC) and prognosis. We analyzed 16S rRNA sequencing data from tumor samples …

Combining p-values from various statistical methods for microbiome data

H Ham, T Park - Frontiers in Microbiology, 2022 - frontiersin.org
Motivation In the field of microbiome analysis, there exist various statistical methods that
have been developed for identifying differentially expressed features, that account for the …

Integration of Omics Data to Explore Heterogeneity in Colorectal Cancer

A Gagliardi - 2024 - iris.unito.it
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancerrelated deaths worldwide. Recent advancements in high-throughput technologies …