Anaplastic large cell lymphoma (ALCL) was first described in 1985 as a large-cell neoplasm
with anaplastic morphology immunostained by the Ki-1 antibody, which recognizes CD30. In …

Abstract Nucleophosmin 1 (NPM1) is a nucleolar phosphoprotein that performs diverse
biological functions including molecular chaperoning, ribosome biogenesis, DNA repair …

AMPylation is a post-translational modification in which AMP is added to the amino acid side
chains of proteins,. Here we show that, with ATP as the ligand and actin as the host activator …

The spectrum of cutaneous CD30-positive lymphoproliferative disorders (LPDs) includes
lymphomatoid papulosis and primary cutaneous anaplastic large cell lymphoma …

Background and Objective: This review comprehensively explores the intricate landscape of
anaplastic lymphoma kinase (ALK), focusing specifically on its pivotal role in non-small cell …

In the last few years, the development of targeted therapies for non-small cell lung cancer
(NSCLC) expressing oncogenic driver mutations (eg EGFR) has changed the clinical …

Background Thyroid carcinoma, which is rare in pediatric patients (age 0–18 years) but
more common in adolescent and young adult (AYA) patients (age 15–39 years), carries the …

The programmed death-ligands, PD-L1 and PD-L2, reside on tumor cells and can bind with
programmed death-1 protein (PD-1) on T-cells, resulting in tumor immune escape. PD-1 …

Background We have previously characterized 19 ependymal tumors using Giemsa banding
and high-resolution comparative genomic hybridization. The aim of this study was to analyze …

Simple Summary Neuroblastoma (NBL) is the most common extracranial cancer in children.
High-risk NBL is characterized by bone marrow metastasis and MYCN oncogene …