Abstract Receptor-interacting protein kinase-3 (RIPK3, or RIP3) is an essential protein in the
“programmed” and “regulated” cell death pathway called necroptosis. Necroptosis is …

Cancer is a challenging problem for the global health community, and its increasing burden
necessitates seeking novel and alternative therapies. Most cancers share six basic …

Acute kidney injury (AKI) exhibits high morbidity and mortality. Kidney injury molecule-1
(KIM1) is dramatically upregulated in renal tubules upon injury, and acts as a biomarker for …

New opportunities are needed to increase immune checkpoint blockade (ICB) benefit.
Whereas the interferon (IFN) γ pathway harbors both ICB resistance factors and therapeutic …

Simple Summary Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)
plays an important role in apoptosis and tumor immunosurveillance. Because TRAIL …

Background Cell death triggered by unmitigated endoplasmic reticulum (ER) stress plays an
important role in physiology and disease, but the death-inducing signaling mechanisms are …

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-based therapy is currently
evaluated in clinical studies as a tumor cell selective pro-apoptotic approach. However …

TRADD (TNFR1-associated death domain protein) was initially identified as an adaptor
molecule that transduces the signal downstream of the TNFR1 (tumor necrosis factor …

Death receptors are members of the tumour necrosis factor (TNF) receptor superfamily
characterised by an~ 80 amino acid long alpha-helical fold, termed the death domain (DD) …

We evaluated redundant and receptor-specific activities of TRADD, RIPK1, and FADD in
RIPK3-expressing HeLa cells lacking expression of these proteins or any combination of two …