Personalized cardiac computational models: from clinical data to simulation of infarct-related ventricular tachycardia
A Lopez-Perez, R Sebastian, M Izquierdo… - Frontiers in …, 2019 - frontiersin.org
In the chronic stage of myocardial infarction, a significant number of patients develop life-
threatening ventricular tachycardias (VT) due to the arrhythmogenic nature of the remodeled …
threatening ventricular tachycardias (VT) due to the arrhythmogenic nature of the remodeled …
[HTML][HTML] Machine learning in drug development: Characterizing the effect of 30 drugs on the QT interval using Gaussian process regression, sensitivity analysis, and …
Prolonged QT intervals are a major risk factor for ventricular arrhythmias and a leading
cause of sudden cardiac death. Various drugs are known to trigger QT interval prolongation …
cause of sudden cardiac death. Various drugs are known to trigger QT interval prolongation …
Generating Purkinje networks in the human heart
The Purkinje network is an integral part of the excitation system in the human heart. Yet, to
date, there is no in vivo imaging technique to accurately reconstruct its geometry and …
date, there is no in vivo imaging technique to accurately reconstruct its geometry and …
Sex differences in drug-induced arrhythmogenesis
The electrical activity in the heart varies significantly between men and women and results in
a sex-specific response to drugs. Recent evidence suggests that women are more than …
a sex-specific response to drugs. Recent evidence suggests that women are more than …
Predicting drug‐induced arrhythmias by multiscale modeling
F Sahli Costabal, J Yao, E Kuhl - International journal for …, 2018 - Wiley Online Library
Drugs often have undesired side effects. In the heart, they can induce lethal arrhythmias
such as torsades de pointes. The risk evaluation of a new compound is costly and can take a …
such as torsades de pointes. The risk evaluation of a new compound is costly and can take a …
How drugs modulate the performance of the human heart
Many drugs interact with ion channels in the cells of our heart and trigger heart rhythm
disorders with potentially fatal consequences. Computational modeling can provide …
disorders with potentially fatal consequences. Computational modeling can provide …
Predicting the cardiac toxicity of drugs using a novel multiscale exposure–response simulator
F Sahli Costabal, J Yao, E Kuhl - Computer methods in …, 2018 - Taylor & Francis
A common but serious side effect of many drugs is torsades de pointes, a rhythm disorder
that can have fatal consequences. Torsadogenic risk has traditionally been associated with …
that can have fatal consequences. Torsadogenic risk has traditionally been associated with …
Estimating cardiomyofiber strain in vivo by solving a computational model
Since heart contraction results from the electrically activated contraction of millions of
cardiomyocytes, a measure of cardiomyocyte shortening mechanistically underlies cardiac …
cardiomyocytes, a measure of cardiomyocyte shortening mechanistically underlies cardiac …
In-silico study of the cardiac arrhythmogenic potential of biomaterial injection therapy
Biomaterial injection is a novel therapy to treat ischemic heart failure (HF) that has shown to
reduce remodeling and restore cardiac function in recent preclinical studies. While the effect …
reduce remodeling and restore cardiac function in recent preclinical studies. While the effect …
Predicting critical drug concentrations and torsadogenic risk using a multiscale exposure-response simulator
FS Costabal, J Yao, A Sher, E Kuhl - Progress in biophysics and molecular …, 2019 - Elsevier
Torsades de pointes is a serious side effect of many drugs that can trigger sudden cardiac
death, even in patients with structurally normal hearts. Torsadogenic risk has traditionally …
death, even in patients with structurally normal hearts. Torsadogenic risk has traditionally …