Human skin pigmentation and melanin synthesis are incredibly variable, and are impacted
by genetics, UV exposure, and some drugs. Patients' physical appearance, psychological …

Microphthalmia-associated transcription factor (MITF) is an important regulator of
melanogenesis and melanocyte development. Although it has been studied extensively in …

BRAF is a member of the RAF family of serine/threonine-specific protein kinases. Oncogenic
BRAF, in particular, BRAF V600E, can disturb the normal protein folding machinery in the …

New effective therapies are greatly needed for metastatic uveal melanoma, which has a very
poor prognosis with a median survival of less than 1 y. The melanocortin 1 receptor (MC1R) …

Background A high total body naevus count is the highest risk factor for melanoma; the
phenotype of red hair colour, freckling and pale skin that burns easily, produced by MC1R R …

Skin pigmentation involves multiple processes, including melanin synthesis, transport, and
melanosome release. Melanin content determines skin color and protects against UV …

Background Uveal melanoma (UM), a rare malignant tumor of the eye, is predominantly
observed in populations of European ancestry. UMs carrying a monosomy 3 (M3) frequently …

Ocular squamous cell carcinoma and infectious keratoconjunctivitis are common ocular
pathologies in Hereford cattle with considerable economic impact. Both pathologies have …

Amelanotic/hypomelanotic melanoma is a clinicopathologic subtype with absent or minimal
melanin. This study assessed previously reported coding variants in albinism genes (TYR …

In recent years, it has been reported that non-coding RNAs, especially microRNAs (miRNAs)
and long non-coding RNAs, act as melanogenesis-regulating molecules in melanocytes. We …