The ribosomal protein S6K (S6 kinase) represents an extensively studied effector of the
TORC1 [TOR (target of rapamycin) complex 1], which possesses important yet incompletely …

The AGC kinase subfamily of protein kinases contains 60 members, including PKA, PKG
and PKC. The family comprises some intensely examined protein kinases (such as Akt, S6K …

New therapeutic approaches to counter the increasing prevalence of obesity and type 2
diabetes mellitus are in high demand. Deregulation of the phosphoinositide-3-kinase …

Eukaryotic ribosomes are substantially larger and more complex than their bacterial
counterparts. Although their core function is conserved, bacterial and eukaryotic protein …

The 70kDa ribosomal protein S6 kinases, S6K1 and S6K2 are two highly homologous
serine/threonine kinases that are activated in response to growth factors, cytokines and …

Insulin-like growth factor (IGF) signaling is fundamental for growth and survival. A large body
of evidence (laboratory, epidemiological, and clinical) implicates the exploitation of this …

S6K1 (p70 ribosomal S6 kinase 1) is activated by insulin and growth factors via the PI3K
(phosphoinositide 3-kinase) and mTOR (mammalian target of rapamycin) signalling …

The group of AGC protein kinases includes more than 60 protein kinases in the human
genome, classified into 14 families: PDK1, AKT/PKB, SGK, PKA, PKG, PKC, PKN/PRK, RSK …

MicroRNAs are a class of small noncoding RNAs that function as critical gene regulators
through targeting mRNAs for translational repression or degradation. In this study, we …

Eukaryotic protein kinases (EPKs) control most biological processes and play central roles
in many human diseases. To become catalytically active, EPKs undergo conversion from an …