Development of halogenase enzymes for use in synthesis

J Latham, E Brandenburger, SA Shepherd… - Chemical …, 2018 - ACS Publications
Nature has evolved halogenase enzymes to regioselectively halogenate a diverse range of
biosynthetic precursors, with the halogens introduced often having a profound effect on the …

Flavoenzymes: versatile catalysts in biosynthetic pathways

CT Walsh, TA Wencewicz - Natural product reports, 2013 - pubs.rsc.org
Covering: up to the end of May 2012 Riboflavin-based coenzymes, tightly bound to enzymes
catalyzing substrate oxidations and reductions, enable an enormous range of chemical …

Baeyer–Villiger monooxygenases: tunable oxidative biocatalysts

MJLJ Fürst, A Gran-Scheuch, FS Aalbers… - ACS …, 2019 - ACS Publications
Pollution, accidents, and misinformation have earned the pharmaceutical and chemical
industry a poor public reputation, despite their undisputable importance to society …

Enzyme fusions in biocatalysis: coupling reactions by pairing enzymes

FS Aalbers, MW Fraaije - ChemBioChem, 2019 - Wiley Online Library
One approach to bringing enzymes together for multienzyme biocatalysis is genetic fusion.
This enables the production of multifunctional enzymes that can be used for whole‐cell …

Homogeneous oxygenase catalysis

Y Liang, J Wei, X Qiu, N Jiao - Chemical reviews, 2018 - ACS Publications
Oxygenases-catalyzed reductive activation of molecular oxygen and incorporation of O
atoms into an organic molecule is undoubtedly one of the most attractive research areas …

The enigmatic reaction of flavins with oxygen

P Chaiyen, MW Fraaije, A Mattevi - Trends in biochemical sciences, 2012 - cell.com
The reaction of flavoenzymes with oxygen remains a fascinating area of research because
of its relevance for reactive oxygen species (ROS) generation. Several exciting recent …

An overview of microbial indigo-forming enzymes

AN Fabara, MW Fraaije - Applied Microbiology and Biotechnology, 2020 - Springer
Indigo is one of the oldest textile dyes and was originally prepared from plant material.
Nowadays, indigo is chemically synthesized at a large scale to satisfy the demand for dyeing …

The oxygen dilemma: a severe challenge for the application of monooxygenases?

D Holtmann, F Hollmann - ChemBioChem, 2016 - Wiley Online Library
Monooxygenases are promising catalysts because they in principle enable the organic
chemist to perform highly selective oxyfunctionalisation reactions that are otherwise difficult …

Characterization and crystal structure of a robust cyclohexanone monooxygenase

E Romero, JRG Castellanos, A Mattevi… - Angewandte Chemie …, 2016 - Wiley Online Library
Cyclohexanone monooxygenase (CHMO) is a promising biocatalyst for industrial reactions
owing to its broad substrate spectrum and excellent regio‐, chemo‐, and enantioselectivity …

[HTML][HTML] The devil is in the details: The chemical basis and mechanistic versatility of flavoprotein monooxygenases

M Toplak, A Matthews, R Teufel - Archives of Biochemistry and Biophysics, 2021 - Elsevier
The ubiquitous flavoenzymes commonly catalyze redox chemistry such as the
monooxygenation of organic substrates and are both widely utilized in nature (eg, in primary …