Bacterial terpenome

JD Rudolf, TA Alsup, B Xu, Z Li - Natural product reports, 2021 - pubs.rsc.org
Covering: up to mid-2020 Terpenoids, also called isoprenoids, are the largest and most
structurally diverse family of natural products. Found in all domains of life, there are over 80 …

Four billion years of microbial terpenome evolution

Y Hoshino, L Villanueva - FEMS microbiology reviews, 2023 - academic.oup.com
Terpenoids, also known as isoprenoids, are the largest and most diverse class of organic
compounds in nature and are involved in many membrane-associated cellular processes …

Mechanism of Radical S-Adenosyl-l-methionine Adenosylation: Radical Intermediates and the Catalytic Competence of the 5′-Deoxyadenosyl Radical

MN Lundahl, R Sarksian, H Yang… - Journal of the …, 2022 - ACS Publications
Radical S-adenosyl-l-methionine (SAM) enzymes employ a [4Fe–4S] cluster and SAM to
initiate diverse radical reactions via either H-atom abstraction or substrate adenosylation …

RaS-RiPPs in Streptococci and the human microbiome

KA Clark, LB Bushin… - ACS bio & med Chem …, 2022 - ACS Publications
Radical S-adenosylmethionine (RaS) enzymes have quickly advanced to one of the most
abundant and versatile enzyme superfamilies known. Their chemistry is predicated upon …

Advances in bacterial pathways for the biosynthesis of ubiquinone

SS Abby, K Kazemzadeh, C Vragniau, L Pelosi… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Ubiquinone is an important component of the electron transfer chains in proteobacteria and
eukaryotes. The biosynthesis of ubiquinone requires multiple steps, most of which are …

On the evolution of coenzyme biosynthesis

A Kirschning - Natural Product Reports, 2022 - pubs.rsc.org
Covering: up to 2022 The report provides a broad approach to deciphering the evolution of
coenzyme biosynthetic pathways. Here, these various pathways are analyzed with respect …

Microbial production of vitamin K2: current status and future prospects

L Ren, C Peng, X Hu, Y Han, H Huang - Biotechnology advances, 2020 - Elsevier
Vitamin K2, also called menaquinone, is an essential lipid-soluble vitamin that plays a
critical role in blood clotting and prevention of osteoporosis. It has become a focus of …

Recent research on the physicochemical properties and biological activities of quinones and their practical applications: a comprehensive review

M Dong, X Ming, T Xiang, N Feng, M Zhang, X Ye… - Food & Function, 2024 - pubs.rsc.org
Quinones represent a class of crude organic compounds ubiquitously distributed in nature.
Their distinctive quinone-type structure confers upon them unique properties and …

Advances in menaquinone biosynthesis: sublocalisation and allosteric regulation

JM Johnston, EMM Bulloch - Current opinion in structural biology, 2020 - Elsevier
Highlights•Menaquinones (MKs) are involved in bacterial electron transport and
adaptation.•The Men pathway is the most predominant of two bacterial pathways to make …

Quinones: more than electron shuttles

T Franza, P Gaudu - Research in Microbiology, 2022 - Elsevier
Bacterial quinones are lipophilic redox compounds involved in important cellular roles such
as electron transport in respiratory and photosynthetic chains. However, a growing body of …