Electrochemical dearomative spirocyclization serves as a green and sustainable approach
to convert the flat, two‐dimension aromatic feedstock into the value‐added three‐dimension …

Spiro compounds are biologically active organic compounds with unique structures, found in
a wide variety of natural products and drugs. They do not readily lead to drug resistance due …

The synthesis of quaternary carbons often requires numerous steps and complex conditions
or harsh reagents that act on heavily engineered substrates. This is largely a consequence …

Presented herein is a novel synthesis of homophthalimide spironaphthalenones from the
cascade reaction of enaminones with diazo homophthalimides. Preliminary mechanistic …

The diastereo‐and enantioselective diboration of spirocyclobutenes provides a platform for
the rapid preparation of a wide variety of chiral spirocyclic building blocks. The …

Spirocycles play an important role in drug discovery and development. The direct, catalytic,
and enantioselective synthesis of spirocycles from readily available starting materials and in …

A catalytic asymmetric [3+ 2] cyclization of novel 4-isothiocyanato pyrazolones and isatin-
derived ketimines was developed, delivering a wide range of intriguing dispirotriheterocyclic …

The chemistry related to the exploration of cyclic N-sulfonyl ketimines and their derivatives
has attracted significant attention in the last few decades because of their intriguing …

Benzofuran-derived azadienes (BDAs) have been widely used as four-atom synthons in
transition-metal-mediated cycloaddition reactions, while the exploitation of their reactivity as …

The Friedel–Crafts type alkylation of C2-tethered thiophenes has been reported to be
nonregioselective. Taking advantage of the highly regioselective 5-exo-trig spirocyclization …