Cyclooxygenases (COX-1 and COX-2) are key enzymes in the conversion of arachidonic
acid to prostaglandins and other lipid mediators. Because it can be induced by inflammatory …

Traumatic brain injury (TBI) is a leading cause of death and disability in young adults
worldwide. TBI survival is associated with persistent neuropsychiatric and neurological …

Three enzyme systems, cyclooxygenases that generate prostaglandins, lipoxygenases that
form hydroxy derivatives and leukotrienes, and epoxygenases that give rise to …

15-Deoxy-Δ-12, 14-prostaglandin J2 (15d-PGJ2) is the most recently discovered
prostaglandin. This cyclopentanone, the dehydration end product of PGD2, differs from other …

Traumatic brain injury (TBI) is a devastating disease, predominantely affecting young
people. Although the prognosis for TBI victims has improved in recent years, many survivors …

Traumatic brain injury (TBI) is a leading cause of death and disability in the United States.
Current medical therapies exhibit limited efficacy in reducing neurological injury and the …

Although traumatic brain injury (TBI) is recognized as one of the leading causes of death
from trauma to the central nervous system (CNS), no known treatment effectively mitigates its …

Neurological diseases are complex diseases affecting the brain and spinal cord, with
numerous etiologies and pathogenesis not yet fully elucidated. Tripterygium wilfordii Hook …

The immune response of the CNS is a defense mechanism activated upon injury to initiate
repair mechanisms while chronic over-activation of the CNS immune system (termed …

Oxidative stress is a major contributor to secondary injury signaling cascades following
traumatic brain injury (TBI). The role of lipid peroxidation in the pathophysiology of a …