Microtubule dynamics and their control are essential for the normal function and division of
all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic …

Axons are electrically excitable, cable-like neuronal processes that relay information
between neurons within the nervous system and between neurons and peripheral target …

An inhibitory extracellular milieu and neuron-intrinsic processes prevent axons from
regenerating in the adult central nervous system (CNS). Here we show how the two aspects …

Reactive oxygen species (ROS) have long been studied as destructive agents in the context
of nervous system ageing, disease and degeneration. Their roles as signalling molecules …

Mammalian neurons lose the ability to regenerate their central nervous system axons as
they mature during embryonic or early postnatal development. Neuronal maturation requires …

During development of the central nervous system (CNS), neurons polarize and rapidly
extend their axons to assemble neuronal circuits. The growth cone leads the axon to its …

The corporeal beauty of the neuronal cytoskeleton has captured the imagination of
generations of scientists. One of the easiest cellular structures to visualize by light …

The specification of an axon and its subsequent outgrowth are key steps during neuronal
polarization, a prerequisite to wire the brain. The Rho-guanosine triphosphatase (GTPase) …

Cortical projection neurons polarize and form an axon while migrating radially. Even though
these dynamic processes are closely interwoven, they are regulated separately—the …

Neurons are among the most morphologically complex cells. A distinction between two
compartments, axon and dendrite, generates cellular domains that differ in membrane …