Natural products, and especially the active ingredients found in traditional Chinese medicine
(TCM), have a thousand-year-long history of clinical use and a strong theoretical basis in …

Quercetin is a kind of flavonoid compounds that comes from nature and is widely existed in
the daily diet. Previous studies have found that quercetin has many effects such as anti …

Multi‐omics usually refers to the crossover application of multiple high‐throughput screening
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …

Abstract Changes in mitochondrial morphology are associated with nutrient utilization, but
the precise causalities and the underlying mechanisms remain unknown. Here, using …

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and
represents the hepatic expression of several metabolic abnormalities of high epidemiologic …

Background Oxidative stress and inflammation play essential roles in the development and
progression of diabetic nephropathy (DN). Baicalin (BAI), a natural flavonoid, has been …

Despite the decline in their proliferative potential, senescent cells display a high metabolic
activity. Senescent cells have been shown to acquire a more glycolytic state even in …

Background Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver
disease and is characterized by excessive hepatic lipid accumulation. Many studies have …

Background and Purpose Disordered lipid metabolism and disturbed mitochondrial
bioenergetics play pivotal roles in the initiation and development of diabetic kidney disease …

Background The loss of tumor antigens and depletion of CD8 T cells caused by the PD-1/PD-
L1 pathway are important factors for tumor immune escape. In recent years, there has been …