Current therapies for heart failure after myocardial infarction are limited and non-curative.
Although regenerative approaches are receiving significant attention, clinical efforts that …

Congenital heart disease (CHD) is the most common congenital anomaly in newborn
babies. Cardiac malformations have been produced in multiple experimental animal …

Organogenesis involves integration of diverse cell types; dysregulation of cell-type-specific
gene networks results in birth defects, which affect 5% of live births. Congenital heart defects …

HAND2 is an ancestral regulator of heart development and one of four transcription factors
that control the reprogramming of fibroblasts into cardiomyocytes,,,. Deletion of Hand2 in …

MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

Cellular reprogramming technology has created new opportunities in understanding human
disease, drug discovery, and regenerative medicine. While a combinatorial code was …

The basic helix-loop-helix (bHLH) family of transcription factors orchestrates cell-fate
specification, commitment and differentiation in multiple cell lineages during development …

The helix-loop-helix (HLH) family of transcriptional regulatory proteins are key players in a
wide array of developmental processes. Over 240 HLH proteins have been identified to date …

MicroRNAs (miRNAs) are genomically encoded small RNAs used by organisms to regulate
the expression of proteins generated from messenger RNA transcripts. The in vivo …

Gradients of signalling and transcription factors govern many aspects of embryogenesis,
highlighting the need for spatiotemporal control of regulatory protein levels. MicroRNAs are …