Ewing sarcoma—diagnosis, treatment, clinical challenges and future perspectives
SK Zöllner, JF Amatruda, S Bauer, S Collaud… - Journal of clinical …, 2021 - mdpi.com
Ewing sarcoma, a highly aggressive bone and soft-tissue cancer, is considered a prime
example of the paradigms of a translocation-positive sarcoma: a genetically rather simple …
example of the paradigms of a translocation-positive sarcoma: a genetically rather simple …
Ewing's sarcoma
N Riggi, ML Suvà, I Stamenkovic - New England Journal of …, 2021 - Mass Medical Soc
Ewing's Sarcoma Ewing's sarcoma, an aggressive cancer of bone and soft tissue, primarily
affects children and young adults. A t (11; 22) translocation is noted in 85 to 90% of cases …
affects children and young adults. A t (11; 22) translocation is noted in 85 to 90% of cases …
Ewing's sarcoma
NJ Balamuth, RB Womer - The lancet oncology, 2010 - thelancet.com
Progress in the treatment of Ewing's sarcoma, the second most common bone tumour in
children and adolescents, has improved survival from about 10% in the period before …
children and adolescents, has improved survival from about 10% in the period before …
Ewing's sarcoma family of tumors: current management
M Bernstein, H Kovar, M Paulussen, RL Randall… - The …, 2006 - academic.oup.com
Abstract Learning Objectives After completing this course, the reader will be able to:
Describe the presentation, differential diagnosis, and prognosis for patients with Ewing's …
Describe the presentation, differential diagnosis, and prognosis for patients with Ewing's …
Updates on cytogenetics and molecular genetics of bone and soft tissue tumors:: Ewing sarcoma and peripheral primitive neuroectodermal tumors
AA Sandberg, JA Bridge - Cancer genetics and cytogenetics, 2000 - Elsevier
Cytogenetics of Bone and Soft Tissue Tumors [1]. In view of the remarkable developments in
this field since 1994, both in the cytogenetic and particularly in the molecular genetic …
this field since 1994, both in the cytogenetic and particularly in the molecular genetic …
EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma.
E De Alava, A Kawai, JH Healey, I Fligman… - Journal of Clinical …, 1998 - ascopubs.org
PURPOSE More than 90% of Ewing's sarcomas (ES) contain a fusion of the EWS and FLI1
genes, due to the t (11; 22)(q24; q12) translocation. At the molecular level, the EWS-FLI1 …
genes, due to the t (11; 22)(q24; q12) translocation. At the molecular level, the EWS-FLI1 …
EWS-FLI-1 expression triggers a Ewing's sarcoma initiation program in primary human mesenchymal stem cells
Ewing's sarcoma family tumors (ESFT) express the EWS-FLI-1 fusion gene generated by the
chromosomal translocation t (11; 22)(q24; q12). Expression of the EWS-FLI-1 fusion protein …
chromosomal translocation t (11; 22)(q24; q12). Expression of the EWS-FLI-1 fusion protein …
EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding …
Ewing tumors are characterized by abnormal transcription factors resulting from the
oncogenic fusion of EWS with members of the ETS family, most commonly FLI-1. RNA …
oncogenic fusion of EWS with members of the ETS family, most commonly FLI-1. RNA …
Promiscuous partnerships in Ewing's sarcoma
S Sankar, SL Lessnick - Cancer genetics, 2011 - Elsevier
Ewing's sarcoma is a highly aggressive bone and soft tissue tumor of children and young
adults. At the molecular genetic level Ewing's sarcoma is characterized by a balanced …
adults. At the molecular genetic level Ewing's sarcoma is characterized by a balanced …
Molecular biology of the Ewing's sarcoma/primitive neuroectodermal tumor family
E de Alava, WL Gerald - Journal of Clinical Oncology, 2000 - ascopubs.org
Ewing's sarcoma (ES) and primitive neuroectodermal tumor (PNET) are members of a tumor
family consistently associated with chromosomal translocation and functional fusion of the …
family consistently associated with chromosomal translocation and functional fusion of the …