Peroxisomes are organelles bounded by a single membrane that can be found in all major
groups of eukaryotes. A single evolutionary origin of this cellular compartment is supported …

More than half a century of research on peroxisomes has revealed unique features of this
ubiquitous subcellular organelle, which have often been in disagreement with existing …

Peroxisomes account for~ 35% of total H2O2 generation in mammalian tissues. Peroxisomal
ACOX 1 (acyl‐CoA oxidase 1) is the first and rate‐limiting enzyme in fatty acid β‐oxidation …

Human cells are able to sense and adapt to variations in oxygen levels. Historically, much
research in this field has focused on hypoxia-inducible factor (HIF) signaling and reactive …

Abstract X-linked adrenoleukodystrophy (X-ALD) is a fatal neurodegenerative disorder,
characterized by progressive cerebral demyelination cerebral childhood …

Tail-anchored (TA) proteins contain a single transmembrane domain (TMD) at the C-
terminus that anchors them to the membranes of organelles where they mediate critical …

We show that a comprehensive set of 16 peroxisomal membrane proteins (PMPs)
encompassing all types of membrane topologies first target to the endoplasmic reticulum …

Cancer is irrevocably linked to aberrant metabolic processes. While once considered a
vestigial organelle, we now know that peroxisomes play a central role in the metabolism of …

Protein translocation across the peroxisomal membrane requires the concerted action of
numerous peroxins. One central component of this machinery is Pex5p, the cycling receptor …

The type-2 peroxisomal targeting signal (PTS2) is one of two peptide motifs destining
soluble proteins for peroxisomes. This signal acts as amphiphilic α-helix exposing the side …