Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

In recent years many efforts have been devoted to the screening and the study of new solid-
state forms of old active pharmaceutical ingredients (APIs) with salification or co …

Molecular materials based on small organic molecules often require advanced structural
analysis, beyond the capability of spectroscopic techniques, to fully characterise them. In …

Preformulation measurements are used to estimate the fraction absorbed in vivo for orally
administered compounds and thereby allow an early evaluation of the need for enabling …

A significant amount of attention has been given to the design and synthesis of co‐crystals
by both industry and academia because of its potential to change a molecule's …

Ionic liquids (ILs) are organic salts with a melting point below 100° C. Active pharmaceutical
ingredients (APIs) are transformed into ILs by combining them with typically large yet …

The advancement of single-crystal structural analysis has emerged as a pivotal technology
surpassing spectroscopic methods in revealing the intricate structural details of organic …

Pharmaceutical salt formation is the most preferred and effective method to enhance the
physicochemical properties of an active pharmaceutical ingredient (API) such as solubility …

The conventional method of hygroscopicity determination proposed by Callahan and co-
workers utilizes more sample and time, may not be precise in all the cases, and is a …

Salification has a successful track record in modulating the biopharmaceutical properties of
drugs. This is evident from the significant share (40%) of pharmaceutical salts in FDA …