Over the past decade, long-read, single-molecule DNA sequencing technologies have
emerged as powerful players in genomics. With the ability to generate reads tens to …

The wide implementation of next-generation sequencing (NGS) technologies has
revolutionized the field of medical genetics. However, the short read lengths of currently …

DNA sequencing has revolutionized medicine over recent decades. However, analysis of
large structural variation and repetitive DNA, a hallmark of human genomes, has been …

Genomic sequencing technologies have revolutionized mutation detection of the genetic
diseases in the past few years. In recent years, the third generation sequencing (TGS) has …

In the past several years, single-molecule sequencing platforms, such as those by Pacific
Biosciences and Oxford Nanopore Technologies, have become available to researchers …

Studies of de novo mutation (DNM) have typically excluded some of the most repetitive and
complex regions of the genome because these regions cannot be unambiguously mapped …

Abstract Purpose Structural variants (SVs) play an important role in inherited retinal
diseases (IRD). Although the identification of SVs significantly improved upon the availability …

Background Long-read sequencing (LRS) techniques have been very successful in
identifying structural variants (SVs). However, the high error rate of LRS made the detection …

During the past decade, the search for pathogenic mutations in rare human genetic
diseases has involved huge efforts to sequence coding regions, or the entire genome, using …

Microbial degradation of chlortetracycline (CTC) is an effective bioremediation method. In
the present study, an enrichment technique was used to isolate a Bacillus cereus LZ01 …