Doxorubicin is utilized for anti-neoplastic treatment for several decades. The utility of this
drug is limited due to its side effects. Generally, doxorubicin toxicity is originated from the …

Heart disease is the leading cause of death worldwide. Cardiomyopathy is a disease
characterized by the heart muscle damage, resulting heart in a structurally and functionally …

Clinical application of doxorubicin (DOX), an anthracycline antibiotic with potent anti-tumor
effects, is limited because of its cardiotoxicity. However, its pathogenesis is still not entirely …

Mammalian soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols
through the addition of a water molecule. sEH readily hydrolyzes lipid signaling molecules …

Chemobrain refers to a common sequelae experienced by 15–80% of cancer patients
exposed to chemotherapeutics. The antineoplastic agent doxorubicin (DOX) has been …

Dioscin shows active effects against renal ischemia/reperfusion injury and
lipopolysaccharide-induced inflammatory kidney injury, however, little is known concerning …

Anthracyclines such as doxorubicin (Dox) are effective chemotherapies, but their use is
limited by cardiac toxicity. We hypothesized that plasma proteomics in women with breast …

Recently, chemotherapy has been one of the most important therapeutic approaches for
malignant tumors. The tumor tissular or intracellular microenvironment-sensitive polymer …

Background The dose-dependent toxicities of doxorubicin (DOX) limit its clinical
applications, particularly in drug-resistant cancers, such as liver cancer. In this study, we …

Doxorubicin (DOX) is a chemotherapeutic drug widely used for the treatment of various
neoplastic conditions. However, its application is limited because of its toxic effects in many …