A noticeable increase in molecular complexity of drug targets has created an unmet need in
the therapeutic agents that are larger than traditional small molecules. Macrocycles, which …

Organic molecules as well as metal complexes may exist as several geometric isomers1
which display distinct physical properties and chemical reactivities. A molecule containing …

Cyclosporine A therapy for prophylaxis against graft rejection revolutionized human organ
transplantation. The immunosuppressant drugs cyclosporin A (CsA), FK506 and rapamycin …

Advances in molecular biology have had a dramatic impact on the drug discovery process.
1, 2 The ability to produce recombinant proteins of biological significance has greatly …

For decades, the development of peptides as potential drugs was aimed solely at peptides
with the highest affinity, receptor selectivity, or stability against enzymatic degradation …

Information recovered from genome sequencing projects, multiple sequence alignments,
structural analyses of PPIase and published records were used in deciphering the biological …

Cell–cell and cell–matrix interactions play a major role in biology. An important class of
surface receptors are the integrins, which exist in a number of subtypes and are involved in …

Two sequence‐unrelated families of proteins possess peptidylproline cis‐trans‐isomerase
activities (PPlase). PPlases are highly sequence conserved and multifunctional proteins …

Based on recent X‐ray structural information, six site‐directed mutants of human cyclophilin
A (hCyPA) involving residues in the putative active site‐H54, R55, F60, Q111, F113, and …

Abstract Changes in the conformation of the units within the peptide chain are the
elementary processes in the folding of a protein into its native three‐dimensional structure …