Peripheral nerve injury is common especially among young individuals. Although injured
neurons have the ability to regenerate, the rate is slow and functional outcomes are often …

The assembly of functional neuronal networks in the developing animal relies on the
polarization of neurons, ie, the formation of a single axon and multiple dendrites. Breaking …

Schwann cell–derived exosomes communicate with dorsal root ganglia (DRG) neurons. The
current study investigated the therapeutic effect of exosomes derived from healthy Schwann …

The vascular system–through its development, response to injury, and remodeling during
disease–constitutes one of the key organ systems sustaining normal human physiology; …

Motor axons in peripheral nerves have the capacity to regenerate after injury. However, full
functional motor recovery rarely occurs clinically, and this depends on the nature and …

Injuries and diseases of the peripheral nervous system (PNS) are common but frequently
irreversible. It is often but mistakenly assumed that peripheral neuron regeneration is robust …

Numerous experimental studies demonstrate that the Ras homolog family of guanosine
triphosphate hydrolases (Rho GTPases) Ras homolog family member A (RhoA), Ras-related …

Regenerative failure in the CNS largely depends on pronounced growth inhibitory signaling
and reduced cellular survival after a lesion stimulus. One key mediator of growth inhibitory …

Following peripheral nerve injury, the distal nerve is primed for regenerating axons by
generating a permissive environment replete with glial cells, cytokines, and neurotrophic …

Non-surgical approaches have been developed to enhance nerve recovery, which are
complementary to surgery, and are an adjunct to the reinnervation process. A search of …