Direct deleterious effects of aldosterone in the heart include development of myocardial
hypertrophy, ventricular remodeling, proarrhythmogenic effects, myocardial ischemia …

Aldosterone, a steroid hormone with mineralocorticoid activity, is mainly recognized for its
action on sodium reabsorption in the distal nephron of the kidney, which is mediated by the …

Background Treatment with angiotensin‐converting enzyme inhibitors (ACEi) and
angiotensin receptor blockers (ARB) is used to reduce proteinuria and retard the …

Diuretics have been recommended as first-line treatment of hypertension and are also
valuable in the management of hypervolemia and electrolyte disorders. This review …

Inhibition of the renin-angiotensin-aldosterone system (RAAS) is a key strategy in treating
hypertension and cardiovascular and renal diseases. However, RAAS inhibitors …

Background and objectives: Addition of aldosterone antagonists (AA) might provide renal
benefits to proteinuric chronic kidney disease (CKD) patients over and above the inhibition …

Diabetic kidney disease (DKD) develops in∼ 40% of patients with diabetes and is the most
common cause of chronic kidney disease (CKD) worldwide. Patients with CKD, especially …

Background: Reductions in albuminuria of more than 30% are considered a strong marker of
delay of chronic kidney disease (CKD) progression. Single renin–angiotensin system (RAS) …

The prevalence of diabetes, hypertension, and cardiovascular disease (CVD) and chronic
kidney disease (CKD) is increasing in concert with obesity. Insulin resistance, metabolic …

The present study was designed to characterize the pharmacological profile of CS-3150, a
novel non-steroidal mineralocorticoid receptor antagonist. In the radioligand-binding assay …