The ubiquitous transcription factor Yin Yang 1 (YY1) is known to have a fundamental role in
normal biologic processes such as embryogenesis, differentiation, replication, and cellular …

DNA cruciforms play an important role in the regulation of natural processes involving DNA.
These structures are formed by inverted repeats, and their stability is enhanced by DNA …

Cancer is one of the most common human diseases. It is long known that mutations in key
regulator genes are hallmarks of all cancer types. Apart from these classical genetic …

The Fbxw7 (F-box/WD repeat–containing protein 7; also called CDC4, Sel10, Ago, and
Fbw7) component of the SCF (Skp1/Cullin/F-box protein) E3 ubiquitin ligase complex acts …

Chronic lymphocytic leukemia (CLL) is an incurable malignancy of B-cells. In this study,
bioinformatics analyses were conducted to identify possible pathogenic roles of CK2α …

Nucleocytoplasmic trafficking of macromolecules, a highly specific and tightly regulated
process, occurs exclusively through the nuclear pore complex. This immense structure is …

Gain of chromosome 6p is a consistent feature of advanced melanomas. However, the
identity of putative oncogene (s) associated with this amplification has remained elusive …

The DEK proto-oncogene has been associated with human carcinogenesis—either as a
fusion with the CAN nucleoporin protein or when transcriptionally upregulated. Mechanisms …

Novel therapeutics are required for improving the management of chronic inflammatory
diseases. Aptamers are single-stranded RNA or DNA molecules that have recently shown …

The paediatric eye tumour retinoblastoma is initiated by inactivation of RB1, a tumour
suppressor on chromosome 13q. In addition to RB1 loss, many retinoblastomas show other …