Sarcoma treatment in the era of molecular medicine
Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers.
Although constituting only 1% of all human malignancies, sarcomas represent the second …
Although constituting only 1% of all human malignancies, sarcomas represent the second …
Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours
The spectrum of tumours arising in childhood is fundamentally different from that seen in
adults, and they are known to be divergent from adult malignancies in terms of cellular …
adults, and they are known to be divergent from adult malignancies in terms of cellular …
Current and future treatment strategies for rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, and can be
subcategorized histologically and/or based on PAX-FOXO1 fusion gene status. Over the last …
subcategorized histologically and/or based on PAX-FOXO1 fusion gene status. Over the last …
Improving immunotherapy efficacy in soft-tissue sarcomas: A biomarker driven and histotype tailored review
M Roulleaux Dugage, EF Nassif, A Italiano… - Frontiers in …, 2021 - frontiersin.org
Anti-PD-(L) 1 therapies yield a disappointing response rate of 15% across soft-tissue
sarcomas, even if some subtypes benefit more than others. The proportions of TAMs and …
sarcomas, even if some subtypes benefit more than others. The proportions of TAMs and …
Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes
Pediatric malignancies including Ewing sarcoma (EwS) feature a paucity of somatic
alterations except for pathognomonic driver-mutations that cannot explain overt variations in …
alterations except for pathognomonic driver-mutations that cannot explain overt variations in …
Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer
Chromosomal instability (CIN) is a hallmark of cancer. Yet, many childhood cancers, such as
Ewing sarcoma (EwS), feature remarkably 'silent'genomes with minimal CIN. Here, we show …
Ewing sarcoma (EwS), feature remarkably 'silent'genomes with minimal CIN. Here, we show …
Glycoproteogenomics: setting the course for next-generation cancer neoantigen discovery for cancer vaccines
Molecular-assisted precision oncology gained tremendous ground with high-throughput
next-generation sequencing (NGS), supported by robust bioinformatics. The quest for …
next-generation sequencing (NGS), supported by robust bioinformatics. The quest for …
Targeting the CALCB/RAMP1 axis inhibits growth of Ewing sarcoma
Ewing sarcoma (EwS) is an aggressive cancer characterized by chromosomal
translocations generating fusions of the EWSR1 gene with ETS transcription factors (in 85 …
translocations generating fusions of the EWSR1 gene with ETS transcription factors (in 85 …
Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma
A Marchetto, S Ohmura, MF Orth, MML Knott… - Nature …, 2020 - nature.com
Ewing sarcoma (EwS) is an aggressive childhood cancer likely originating from
mesenchymal stem cells or osteo-chondrogenic progenitors. It is characterized by fusion …
mesenchymal stem cells or osteo-chondrogenic progenitors. It is characterized by fusion …
The Value of Microbes in Cancer Neoantigen Immunotherapy
J Tian, J Ma - Pharmaceutics, 2023 - mdpi.com
Tumor neoantigens are widely used in cancer immunotherapy, and a growing body of
research suggests that microbes play an important role in these neoantigen-based …
research suggests that microbes play an important role in these neoantigen-based …