The intestinal barrier and current techniques for the assessment of gut permeability

I Schoultz, ÅV Keita - Cells, 2020 - mdpi.com
The intestinal barrier is essential in human health and constitutes the interface between the
outside and the internal milieu of the body. A functional intestinal barrier allows absorption of …

[HTML][HTML] All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases

A Fasano - F1000Research, 2020 - ncbi.nlm.nih.gov
Improved hygiene leading to reduced exposure to microorganisms has been implicated as
one possible cause for the recent “epidemic” of chronic inflammatory diseases (CIDs) in …

The role of intestinal permeability in gastrointestinal disorders and current methods of evaluation

T Vanuytsel, J Tack, R Farre - Frontiers in Nutrition, 2021 - frontiersin.org
An increased intestinal permeability has been described in various gastrointestinal and non-
gastrointestinal disorders. Nevertheless, the concept and definition of intestinal permeability …

Biomarkers for assessment of intestinal permeability in clinical practice

B Seethaler, M Basrai, AM Neyrinck… - American Journal …, 2021 - journals.physiology.org
Intestinal permeability is an important diagnostic marker, yet its determination by established
tests, which measure the urinary excretion of orally administered tracer molecules, is time …

Adipose tissue derived bacteria are associated with inflammation in obesity and type 2 diabetes

L Massier, R Chakaroun, S Tabei, A Crane, KD Didt… - Gut, 2020 - gut.bmj.com
Objective Bacterial translocation to various organs including human adipose tissue (AT) due
to increased intestinal permeability remains poorly understood. We hypothesised that:(1) …

Serum zonulin as a marker of intestinal mucosal barrier function: May not be what it seems

M Ajamian, D Steer, G Rosella, PR Gibson - PloS one, 2019 - journals.plos.org
The protein, zonulin, has emerged as a popular serological marker to assess the integrity of
the intestinal mucosal barrier. However, there is limited information on the utility of serum …

Impaired intestinal barrier and tissue bacteria: pathomechanisms for metabolic diseases

L Massier, M Blüher, P Kovacs… - Frontiers in …, 2021 - frontiersin.org
An intact intestinal barrier, representing the interface between inner and outer environments,
is an integral regulator of health. Among several factors, bacteria and their products have …

Assessment of exercise-associated gastrointestinal perturbations in research and practical settings: methodological concerns and recommendations for best practice

RJS Costa, P Young, SK Gill… - … journal of sport …, 2022 - journals.humankinetics.com
Strenuous exercise is synonymous with disturbing gastrointestinal integrity and function,
subsequently prompting systemic immune responses and exercise-associated …

[HTML][HTML] Intestinal permeability in type 1 diabetes: An updated comprehensive overview

MØ Mønsted, ND Falck, K Pedersen, K Buschard… - Journal of …, 2021 - Elsevier
The etiopathogenesis of the autoimmune disease type 1 diabetes (T1D) is still largely
unknown, however, both genetic and environmental factors contribute to the development of …

Zonulin as a potential therapeutic target in microbiota-gut-brain axis disorders: encouraging results and emerging questions

A Veres-Székely, C Szász, D Pap, B Szebeni… - International journal of …, 2023 - mdpi.com
The relationship between dysbiosis and central nervous diseases has been proved in the
last 10 years. Microbial alterations cause increased intestinal permeability, and the …