The human genetic epidemiology of COVID-19
Human genetics can inform the biology and epidemiology of coronavirus disease 2019
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …
Machine learning and algorithmic fairness in public and population health
Until now, much of the work on machine learning and health has focused on processes
inside the hospital or clinic. However, this represents only a narrow set of tasks and …
inside the hospital or clinic. However, this represents only a narrow set of tasks and …
Genetic associations of protein-coding variants in human disease
Genome-wide association studies (GWAS) have identified thousands of genetic variants
linked to the risk of human disease. However, GWAS have so far remained largely …
linked to the risk of human disease. However, GWAS have so far remained largely …
Risk factors for human papillomavirus infection, cervical intraepithelial neoplasia and cervical cancer: an umbrella review and follow-up Mendelian randomisation …
Background Persistent infection by oncogenic human papillomavirus (HPV) is necessary
although not sufficient for development of cervical cancer. Behavioural, environmental, or …
although not sufficient for development of cervical cancer. Behavioural, environmental, or …
Relationship between NAFLD and coronary artery disease: A Mendelian randomization study
Relationship between NAFLD and coronary artery disease: A Me... : Hepatology Relationship
between NAFLD and coronary artery disease: A Mendelian randomization study : Hepatology …
between NAFLD and coronary artery disease: A Mendelian randomization study : Hepatology …
Mendel's laws, Mendelian randomization and causal inference in observational data: substantive and nomenclatural issues
We respond to criticisms of Mendelian randomization (MR) by Mukamal, Stampfer and Rimm
(MSR). MSR consider that MR is receiving too much attention and should be renamed. We …
(MSR). MSR consider that MR is receiving too much attention and should be renamed. We …
Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis
Cholesterol biosynthetic intermediates, such as lanosterol and desmosterol, are emergent
immune regulators of macrophages in response to inflammatory stimuli or lipid overloading …
immune regulators of macrophages in response to inflammatory stimuli or lipid overloading …
Finding genetically-supported drug targets for Parkinson's disease using Mendelian randomization of the druggable genome
CS Storm, DA Kia, MM Almramhi… - Nature …, 2021 - nature.com
Parkinson's disease is a neurodegenerative movement disorder that currently has no
disease-modifying treatment, partly owing to inefficiencies in drug target identification and …
disease-modifying treatment, partly owing to inefficiencies in drug target identification and …
Selecting likely causal risk factors from high-throughput experiments using multivariable Mendelian randomization
Modern high-throughput experiments provide a rich resource to investigate causal
determinants of disease risk. Mendelian randomization (MR) is the use of genetic variants as …
determinants of disease risk. Mendelian randomization (MR) is the use of genetic variants as …
Non-alcoholic fatty liver disease and cardiovascular disease: assessing the evidence for causality
MCGJ Brouwers, N Simons, CDA Stehouwer, A Isaacs - Diabetologia, 2020 - Springer
Non-alcoholic fatty liver disease (NAFLD) is highly prevalent among individuals with type 2
diabetes. Although epidemiological studies have shown that NAFLD is associated with …
diabetes. Although epidemiological studies have shown that NAFLD is associated with …