The intervertebral disc (IVD) aids in motion and acts to absorb energy transmitted to the
spine. With little inherent regenerative capacity, degeneration of the intervertebral disc …

Osteoarthritis (OA) is a chronic degenerative disease afflicting millions globally. Despite the
development of numerous pharmacological treatments for OA, a substantial unmet need for …

Chronic low back pain mainly attributed to intervertebral disc (IVD) degeneration.
Endogenous damage-associated molecular patterns (DAMPs) in the injured IVD, particularly …

Inflammatory pain (IP) is one of the most prevalent and intractable human conditions, and it
leads to progressive dysfunction and reduced quality of life. Additionally, IP is incredibly …

Cell transplantation is being actively explored as a regenerative therapy for discogenic back
pain. This study explored the regenerative potential of Tie2+ nucleus pulposus progenitor …

Pain is estimated to affect more than 20% of the global population, imposing incalculable
health and economic burdens. Effective pain management is crucial for individuals suffering …

Background Intervertebral disc degeneration (IDD) is a major cause of low back pain (LBP)
worldwide. Sexual dimorphism, or sex‐based differences, appear to exist in the severity of …

Painful musculoskeletal disorders such as intervertebral disc (IVD) degeneration associated
with chronic low back pain (termed “Discogenic back pain”, DBP), are a significant socio …

Intervertebral disc degeneration (IVDD) is a predominant cause of disc herniation and is
widespread worldwide. Inflammatory responses, mitochondrial dysfunction, and …

Synapses serve as the interface for the transmission of information between neurons in the
central nervous system. The structural and functional characteristics of synapses are highly …