Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration—Insights into disease mechanisms and current therapeutic approaches

N Huber, S Korhonen, D Hoffmann, S Leskelä… - Molecular …, 2022 - nature.com
Frontotemporal lobar degeneration (FTLD) comprises a heterogenous group of fatal
neurodegenerative diseases and, to date, no validated diagnostic or prognostic biomarkers …

[HTML][HTML] Elucidating the potential side effects of current anti-seizure drugs for epilepsy

E Akyüz, B Köklü, C Ozenen, A Arulsamy… - Current …, 2021 - ncbi.nlm.nih.gov
Over the decades, various interventions have been developed and utilized to treat epilepsy.
However, the majority of epileptic patients are often first prescribed anti-epileptic drugs …

[HTML][HTML] Epilepsy and the gut: Perpetrator or victim?

M Al-Beltagi, NK Saeed - World Journal of Gastrointestinal …, 2022 - ncbi.nlm.nih.gov
The brain and the gut are linked together with a complex, bi-path link known as the gut-brain
axis through the central and enteric nervous systems. So, the brain directly affects and …

α6GABAA Receptor Positive Modulators Alleviate Migraine-like Grimaces in Mice via Compensating GABAergic Deficits in Trigeminal Ganglia

HR Tzeng, MT Lee, PC Fan, DE Knutson, TH Lai… - …, 2021 - Springer
Migraine is caused by hyperactivity of the trigeminovascular system, where trigeminal
ganglia (TG) play an important role. This hyperactivity might originate from an …

[HTML][HTML] Topiramate

KA Fariba, A Saadabadi - StatPearls [Internet], 2023 - ncbi.nlm.nih.gov
Objectives: Describe the mechanism of action of topiramate. Identify the indications of
topiramate. Review the appropriate monitoring of topiramate. Outline some interprofessional …

Pain sensitivities predict prophylactic treatment outcomes of flunarizine in chronic migraine patients: A prospective study

LLH Pan, YF Wang, YH Ling, KL Lai, SP Chen… - …, 2022 - journals.sagepub.com
Background We aimed to assess the differences in quantitative sensory testing between
chronic migraine and healthy controls and to explore the association between pain …

The interplay between microbiota and brain-gut axis in epilepsy treatment

H Zhu, W Wang, Y Li - Frontiers in Pharmacology, 2024 - frontiersin.org
The brain-gut axis plays a vital role in connecting the cognitive and emotional centers of the
brain with the intricate workings of the intestines. An imbalance in the microbiota-mediated …

Anticonvulsant Classes and Possible Mechanism of Actions

WH Abd-Allah, MA El-Mohsen Anwar… - ACS Chemical …, 2023 - ACS Publications
Epilepsy is considered one of the most common neurological disorders worldwide; it needs
long-term or life-long treatment. Despite the presence of several novel antiepileptic drugs …

Efficacy of Cicuta virosa medicinal preparations against pentylenetetrazole-induced seizures

P Mishra, JK Sinha, SK Rajput - Epilepsy & Behavior, 2021 - Elsevier
Epileptic seizures are characterized by imbalanced inhibition-excitation cycle that triggers
biochemical alterations responsible for jeopardized neuronal integrity. Conventional …

Utilization of epilepsy care among Women Veterans: A population-based study

E Sullivan-Baca, SA Lorkiewicz, R Rehman… - Epilepsy Research, 2023 - Elsevier
Objective Higher healthcare utilization in epilepsy correlates with better clinical and quality
of life outcomes. Women Veterans with epilepsy (WVE) have unique characteristics that may …