The mammalian gut microbial community, known as the gut microbiota, comprises trillions of
bacteria, which co-evolved with the host and has an important role in a variety of host …

Since the first genome-scale comparisons, it has been evident that the genomes of many
species are unbound by strict vertical descent: Large differences in gene content can occur …

Whole-genome sequences are now available for many microbial species and clades,
however existing whole-genome alignment methods are limited in their ability to perform …

Although Escherichia coli can be an innocuous resident of the gastrointestinal tract, it also
has the pathogenic capacity to cause significant diarrheal and extraintestinal diseases …

The existence of large amounts of within-species genome content variability is puzzling.
Population genetics tells us that fitness effects of new variants—either deleterious, neutral or …

A dense resident microbial community in the gut, referred as the commensal microbiota,
coevolved with the host and is essential for many host physiological processes that include …

Sandwich lateral flow immunoassays (LFIAs) based on paired antibodies are the most
frequently used platform for food-borne pathogen detection. Although label-free strategies …

Background Multiple genome alignment remains a challenging problem. Effects of
recombination including rearrangement, segmental duplication, gain, and loss can create a …

Escherichia coli is a versatile bacterial species that includes both harmless commensal
strains and pathogenic strains found in the gastrointestinal tract in humans and warm …

Background Visualisation of genome comparisons is invaluable for helping to determine
genotypic differences between closely related prokaryotes. New visualisation and …