Abstract Purpose of Review Juvenile-onset systemic lupus erythematosus ((j) SLE) is an
autoimmune/inflammatory disease that results in significant damage and disability. When …

Genetic variation was first shown to be important in systemic lupus erythematosus (SLE or
lupus) in the 1970s with associations in the human leukocyte antigen region. Almost four …

Humans differ in the outcome that follows exposure to life-threatening pathogens, yet the
extent of population differences in immune responses and their genetic and evolutionary …

Offering up-to-date, comprehensive coverage of disease progression, diagnosis,
management, and prognosis, Textbook of Pediatric Rheumatology is the definitive reference …

An estimated 10% to 20% of patients experience the onset of systemic lupus erythematosus
(SLE) before adulthood. More precise estimates are difficult due to a lack of a clear age limit …

There is growing evidence that preceding the diagnosis or classification of systemic lupus
erythematosus (SLE), patients undergo a preclinical phase of disease where markers of …

Genome-wide association studies and fine mapping of candidate regions have rapidly
advanced our understanding of the genetic basis of systemic lupus erythematosus (SLE) …

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disorder with a complex
pathogenesis in which genetic, hormonal and environmental factors have a role. Rare …

A combined forward and reverse genetic approach was undertaken to test the candidacy of
IRAK1 (interleukin-1 receptor associated kinase-1) as an X chromosome-encoded risk factor …

Innate immune signaling plays an important role in inflammation, and dysregulation of
signaling components within this pathway has been focused as a critical mediator in …