A major challenge in hematopoiesis is to conceive assays that could bring useful insights
into experimental and clinical hematology. This means identifying separately the various …

The field of murine models of xenotransplantation has grown immensely over the past two
decades. The explosive growth in this field is in part due to the fact that good in vitro …

In this paper, we confirm data reported by the group of Zúñiga-Pflücker that human cord
blood CD34+ 38− Lin− progenitor cells when co-cultured with the murine stromal cell line …

To evaluate the role of the TCR in the αβ/γδ lineage choice during human thymocyte
development, molecular analyses of the TCRβ locus in γδ cells and the TCRγ and δ loci in …

Background The potential role of the adult thymus in T‐cell homeostasis subsequent to
lymphopenia remains the subject of debate. We examined whether thymic activity …

Newborn babies possess a functional but immature immune system as a defense against a
world teeming with microorganisms. Breast milk contains a number of biological, active …

Hematopoietic precursors (HPCs) entering into the thymus undergo a sequential process
leading to the generation of a variety of T cell subsets. This developmental odyssey unfolds …

An experimental system to explore central tolerance in humans is unavailable. However, the
human endogenous retrovirus K-18 (HERV-K18) region on chromosome 1 provides an …

A major problem after clinical hematopoietic stem cell transplantations is poor T‐cell
reconstitution. Studying the mechanisms underlying this concern is hampered, because …

Background Rho GTPases are involved in the regulation of many cell functions, including
some related to the actin cytoskeleton. Different Rho GTPases have been shown to be …