Antimicrobial resistance is an old and silent pandemic. Resistant organisms emerge in
parallel with new antibiotics, leading to a major global public health crisis over time …

Pseudomonas aeruginosa is an opportunistic pathogen that is a leading cause of morbidity
and mortality in cystic fibrosis patients and immunocompromised individuals. Eradication of …

P. aeruginosa is classified as a priority one pathogen by the World Health Organisation, and
new drugs are urgently needed, due to the emergence of multidrug-resistant (MDR) strains …

Tripartite efflux pumps and the related type 1 secretion systems (T1SSs) in Gram-negative
organisms are diverse in function, energization, and structural organization. They form …

Nanoparticles (NPs) are increasingly used to target bacteria as an alternative to antibiotics.
Nanotechnology may be particularly advantageous in treating bacterial infections. Examples …

Multidrug efflux pumps function at the frontline to protect bacteria against antimicrobials by
decreasing the intracellular concentration of drugs. This protective barrier consists of a …

The spread of bacterial drug resistance has posed a severe threat to public health globally.
Here, we cover bacterial resistance to current antibacterial drugs, including traditional herbal …

Highlights•MDR P. aeruginosa is one of the major causes of the nosocomial
infections.•Virulence factors involved in pathogenicity were described.•Potential inhibitors of …

Membrane proteins play a most important part in metabolism, signaling, cell motility,
transport, development, and many other biochemical and biophysical processes which …

Researchers, clinicians and governments all recognize antimicrobial resistance as a serious
and growing threat worldwide. New antimicrobials are urgently needed, especially for …