Simple Summary Despite recent therapeutic advances against cancer, many patients do not
respond well or respond poorly, to treatment and develop resistance to more than one anti …

Apoptosis is the programmed cell death which maintains the healthy survival/death balance
in metazoan cells. Defect in apoptosis can cause cancer or autoimmunity, while enhanced …

Abstract In 2009, the Nomenclature Committee on Cell Death (NCCD) proposed a set of
recommendations for the definition of distinct cell death morphologies and for the …

REVIEW Apoptosis is a cell suicide mechanism that enables metazoans to control cell
number in tissues and to eliminate individual cells that threaten the animal's survival. Certain …

Abstract Tumour Necrosis Factor α (TNFα), is an inflammatory cytokine produced by
macrophages/monocytes during acute inflammation and is responsible for a diverse range …

APO‐1 (Fas/CD95), a member of the tumor necrosis factor receptor superfamily, induces
apoptosis upon receptor oligomerization. In a search to identify intracellular signaling …

Many diverse activities of tumor necrosis factor (TNF) are signaled through TNF receptor 1
(TNFRl). We have identified a novel 34 kDa protein, designated TRADD, that specifically …

Using the cytoplasmic domain of Fas in the yeast twohybrid system, we have identified a
novel interacting protein, FADD, which binds Fasand Fas-FD5, a mutant of Fas possessing …

▪ Abstract Nerve growth factor (NGF) was discovered 50 years ago as a molecule that
promoted the survival and differentiation of sensory and sympathetic neurons. Its roles in …

Tumor necrosis factor (TNF) can induce apoptosis and activate NF-κB through signaling
cascades emanating from TNF receptor 1 (TNFR1). TRADD is a TNFR1-associated signal …