Transforming growth factor beta-induced (TGFBI) corneal dystrophies are a group of
inherited progressive corneal diseases. Accumulation of transforming growth factor beta …

Transforming growth factor-β-induced protein (TGFBIp), an extracellular matrix protein, is the
second most abundant protein in the corneal stroma. In this review, we summarize the …

High-temperature requirement A1 (HTRA1) is a secreted serine protease reported to play a
role in the development of several cancers and neurodegenerative diseases. Still, the …

The multifunctional protein clusterin (CLU) was first described in 1983 as a secreted
glycoprotein present in ram rete testis fluid that enhanced aggregation ('clustering') of a …

TGFBI p is a constituent of the extracellular matrix in many human tissues including the
cornea, where it is one of the most abundant proteins expressed. TGFBI p interacts with …

A major cause of visual impairment, corneal dystrophies result from accumulation of protein
deposits in the cornea. One of the proteins involved is transforming growth factor β-induced …

Several human proteins cause disease by misfolding and aggregating into amyloid fibril
deposits affecting the surrounding tissues. Multiple other proteins co-associate with the …

Purpose: Transforming growth factor beta-induced (TGFBI)–related dystrophies constitute
the most common heritable forms of corneal dystrophy worldwide. However, other than the …

TGFBI-associated corneal dystrophies are inherited disorders caused by TGFBI gene
variants that promote deposition of mutant protein (TGFBIp) as insoluble aggregates in the …

Purpose In this study, we investigated whether the phenotypic difference observed between
two lattice corneal dystrophy type 1 (LCD type 1) cases caused by either a single A546D …