Ferroptosis is a kind of regulatory cell death (RCD) caused by iron accumulation and lipid
peroxidation, which is characterized by mitochondrial morphological changes and has a …

Hyperuricaemia (increased serum urate concentration) occurs mainly in higher primates,
including in humans, because of inactivation of the gene encoding uricase during primate …

Dietary haem iron intake is linked to an increased risk of type 2 diabetes (T2D), but the
underlying plasma biomarkers are not well understood. We analysed data from 204,615 …

Because of its high prevalence worldwide, osteoporosis is considered a serious public
health concern. Many known risk factors for developing osteoporosis have been identified …

Studies of neurodegenerative disease risk in gout are contradictory. Relationships with
neuroimaging markers of brain structure, which may offer insights, are uncertain. Here we …

We recently reported a previously unknown salutary role for xanthine oxidoreductase (XOR)
in intravascular heme overload whereby hepatocellular export of XOR to the circulation was …

In recent years, the emerging phenomenon of ferroptosis has garnered significant attention
as a distinctive mode of programmed cell death. Distinguished by its reliance on iron and …

Abstract Aims Polygonum cuspidatum Sieb. et Zucc is one of the commonly used herbs for
the treatment of gouty arthritis, and polydatin is one of its main effective components. This …

Although observational studies indicate putative causal effects of serum urate on
comorbidities, Mendelian randomization studies suggest that serum urate does not have a …

Background: Serum urate (SU) levels in primates are extraordinarily high among mammals.
Urate is a Janus-faced molecule that acts physiologically as a protective antioxidant but …