FinnGen provides genetic insights from a well-phenotyped isolated population
Population isolates such as those in Finland benefit genetic research because deleterious
alleles are often concentrated on a small number of low-frequency variants (0.1%≤ minor …
alleles are often concentrated on a small number of low-frequency variants (0.1%≤ minor …
FinnGen: Unique genetic insights from combining isolated population and national health register data
Population isolates such as Finland provide benefits in genetic studies because the allelic
spectrum of damaging alleles in any gene is often concentrated on a small number of low …
spectrum of damaging alleles in any gene is often concentrated on a small number of low …
Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers
Polygenic risk scores (PRSs) have shown promise in predicting susceptibility to common
diseases,–. We estimated their added value in clinical risk prediction of five common …
diseases,–. We estimated their added value in clinical risk prediction of five common …
Association of genetic variation with cirrhosis: a multi-trait genome-wide association and gene–environment interaction study
Background & Aims In contrast to most other common diseases, few genetic variants have
been identified that impact risk of cirrhosis. We aimed to identify new genetic variants that …
been identified that impact risk of cirrhosis. We aimed to identify new genetic variants that …
Evaluating risk for alcohol use disorder: Polygenic risk scores and family history
Background Early identification of individuals at high risk for alcohol use disorder (AUD)
coupled with prompt interventions could reduce the incidence of AUD. In this study, we …
coupled with prompt interventions could reduce the incidence of AUD. In this study, we …
White blood cells and chronic rhinosinusitis: a Mendelian randomization study
T Pongdee, SJ Bielinski, PA Decker, H Kita… - Allergy, Asthma & …, 2022 - Springer
Background Risk factors for the pathogenesis of chronic rhinosinusitis (CRS) remain largely
undetermined, which is likely due to the heterogeneity of the disease. White blood cell …
undetermined, which is likely due to the heterogeneity of the disease. White blood cell …
Genome-wide natural selection signatures are linked to genetic risk of modern phenotypes in the Japanese population
Y Yasumizu, S Sakaue, T Konuma… - Molecular biology …, 2020 - academic.oup.com
Elucidation of natural selection signatures and relationships with phenotype spectra is
important to understand adaptive evolution of modern humans. Here, we conducted a …
important to understand adaptive evolution of modern humans. Here, we conducted a …
[HTML][HTML] Polygenic score for physical activity is associated with multiple common diseases
Methods PRS for device-measured overall PA were adapted to a FinnGen study cohort of
218,792 individuals with genomewide genotyping and extensive digital longitudinal health …
218,792 individuals with genomewide genotyping and extensive digital longitudinal health …
Investigating causal relations between sleep duration and risks of adverse pregnancy and perinatal outcomes: linear and nonlinear Mendelian randomization …
Q Yang, MC Magnus, F Kilpi, G Santorelli, AG Soares… - BMC medicine, 2022 - Springer
Background Observational studies have reported maternal short/long sleep duration to be
associated with adverse pregnancy and perinatal outcomes. However, it remains unclear …
associated with adverse pregnancy and perinatal outcomes. However, it remains unclear …
Investigation of factors that affect the frequency of alcohol use of employees in Turkey
Objectives: The purpose of this study was to determine the socio-demographic and
economic factors affecting the frequency of alcohol use by employees aged 15 and above in …
economic factors affecting the frequency of alcohol use by employees aged 15 and above in …