This Review explores the dynamic behavior of water within nanopores and biological
channels in lipid bilayer membranes. We focus on molecular simulation studies, alongside …

Highlights•pH is vital for the normal functioning of the body.•Drug targeting has been widely
used to increase efficacy and reduce adverse effects.•pH variation in different tissues and …

Membrane proteins are critical functional molecules in the human body, constituting more
than 30% of open reading frames in the human genome. Unfortunately, a myriad of …

Infection of the human stomach by Helicobacter pylori remains a worldwide problem and
greatly contributes to peptic ulcer disease and gastric cancer. Without active intervention …

Antimicrobial peptides (AMPs), as a key component of the immune defense systems of
organisms, are a promising solution to the serious threat of drug-resistant bacteria to public …

The effect of antibiotics in the stomach for curing Helicobacter pylori infection is hampered
by the adverse gastric environment and low bioavailability of the administered drugs …

The architecture of biological membranes is tightly coupled to the localization, organization,
and function of membrane proteins. The organelle-specific distribution of lipids allows for the …

Vaccination is an increasingly important alternative approach to control Helicobacter pylori
infection, since H. pylori resistance to previously efficacious antibiotic regimens is increased …

Although the role of general bacterial porins is well established as main pathway for polar
antibiotics, the molecular details of their mode-of-action are still under debate. Using …

Evolution turned aquaporins (AQPs) into the most efficient facilitators of passive water flow
through cell membranes at no expense of solute discrimination. In spite of a plethora of …