HOX genes convey positional identity that leads to the proper partitioning and adult identity
of the female reproductive track. Abnormalities in reproductive tract development can be …

The basal ganglia, said Kinnear-Wilson in the 1920s, have all the clarity of a dark basement.
And so it has remained for the better part of a century. There are now major new ideas about …

Molecular profiling of single cells has advanced our knowledge of the molecular basis of
development. However, current approaches mostly rely on dissociating cells from tissues …

Spatiotemporal orchestration of gene expression is required for proper embryonic
development. The use of single-cell technologies has begun to provide improved resolution …

The world's most revered and eloquent interpreter of evolutionary ideas offers here a work of
explanatory force unprecedented in our time—a landmark publication, both for its historical …

Transformed stem cells have been isolated from some human cancers. We report that,
unlike other brain cancers, the lethal glioblastoma multiforme contains neural precursors …

By homologous recombination of an internal ribosome entry site and Cre recombinase
coding region into the 3′-untranslated region of the mouse Emx1 gene, we have generated …

Recent studies have shown that defined sets of transcription factors can directly reprogram
differentiated somatic cells to a different differentiated cell type without passing through a …

ABSTRACT β-Catenin is a central component of both the cadherin-catenin cell adhesion
complex and the Wnt signaling pathway. We have investigated the role of β-catenin during …

We demonstrate directed differentiation of telencephalic precursors from mouse embryonic
stem (ES) cells using optimized serum-free suspension culture (SFEB culture). Treatment …