Pyridine-based ring systems are one of the most extensively used heterocycles in the field of
drug design, primarily due to their profound effect on pharmacological activity, which has led …

Histamine is a developmentally highly conserved autacoid found in most vertebrate tissues.
Its physiological functions are mediated by four 7-transmembrane G protein–coupled …

Increasingly, it is being recognised that a balanced modulation of several targets can
provide a superior therapeutic effect and side effect profile compared to the action of a …

Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a
biologically active phospholipid mediator. Although PAF was initially recognized for its …

Platelet-activating factor (PAF) is a potent phospholipid mediator with diverse biological
activities in addition to its well-known ability to stimulate platelet aggregation. Pharmacologic …

Anaphylaxis is an acute, severe, life-threatening multisystem allergic reaction resulting from
the sudden systemic release of biochemical mediators and chemotactic substances …

abstract Pollen from many tree species in the Cupressaceae family is a well-known cause of
seasonal allergic diseases worldwide. Japanese cedar pollinosis and Japanese cypress …

Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a
biologically active phospholipid mediator. Although PAF was named for its potential to …

The symptoms of chronic urticaria, be it chronic spontaneous urticaria (CSU) or chronic
inducible urticaria (CindU), are mediated primarily by the actions of histamine on H1 …

Objective Stress precipitates and worsens not only asthma and atopic dermatitis but also
acute coronary syndromes (ACSs), which are associated with coronary inflammation …