Improvement of the productivity of commercially viable microbial strains is an important field
in microbiology, especially since wildtype strains isolated from nature usually produce only a …

Aromatic polyketides differ from other polyketides by their characteristic polycyclic aromatic
structures. These polyketides are widely distributed in bacteria, fungi, and plants, and many …

We developed a novel approach for improving the production of antibiotic from
Streptomyces coelicolor A3 (2) by inducing combined drug-resistant mutations. Mutants with …

The actinomycetes are well-known bioactive natural product producers, comprising the
Streptomycetes, the richest drug-prolific family in all kingdoms, producing therapeutic …

Working with a Streptomyces albus strain that had previously been bred to produce
industrial amounts (10 mg/ml) of salinomycin, we demonstrated the efficacy of introducing …

Drugs in the chemical space beyond the rule of 5 (bRo5) can modulate targets with difficult
binding sites while retaining cell permeability and oral absorption. Reviewing the syntheses …

Saccharopolyspora erythraea makes erythromycin, an antibiotic commonly used in human
medicine. Unusually, the erythromycin biosynthetic (ery) cluster lacks a pathway-specific …

With the advent of modern tools of molecular biology and genetic engineering and new skills
in metabolic engineering and synthetic biology, fermentation technology for industrial …

An industrial erythromycin production strain of Saccharopolyspora erythraea spp. was used
to demonstrate that careful genetic engineering can significantly improve productivity. The …

Streptomycetes are Gram-positive, soil-inhabiting bacteria of the order Actinomycetales.
These organisms exhibit an unusual, developmentally complex life cycle and produce many …