Highlights•The dramatic efficacy of CAR T cell therapy should be weighed up against the
safety risks.•The clinical safety profiles present new challenges to immuno …

Amphibian skin is a mucosal surface in direct and continuous contact with a microbially
diverse and laden aquatic and/or terrestrial environment. As such, frog skin is an important …

Surgical resection remains the mainstay treatment for solid cancers, especially for localized
disease. However, the postoperative immunosuppression provides a window for cancer cell …

Tumor cells express a high quantity of exosomes packaged with unique cargos under
hypoxia, an important characteristic feature in solid tumors. These hypoxic tumor-derived …

Depression is a common but serious mental illness; meanwhile, it is also an inflammatory
disorder. Toll-like receptor 4 (TLR4), as the pattern recognition receptor, has been shown to …

The mechanisms underlying secondary brain damage following traumatic brain injury (TBI)
remain unclear. A great many studies have demonstrated that inflammatory cascades …

Background Systemic lupus erythematosus (SLE) is a common autoimmune disease that
affects all organs. Recently, several studies have shown that pyroptosis playsa significant …

Suberin acts as stress‐induced antipathogen barrier in the root cell wall. CYP 86A1 encodes
cytochrome P450 fatty acid ω‐hydroxylase, which has been reported to be a key enzyme for …

Precise regulation of innate immunity is crucial for development of appropriate host immunity
against microbial infections and maintenance of immune homeostasis. MicroRNAs are small …

Pattern recognition receptors (PRRs) are crucial for responses to infections and tissue
damage; however, their role in autoimmunity is less clear. Herein we demonstrate that 2 C …