L-serine synthesis via the phosphorylated pathway in humans
L-serine is a nonessential amino acid in eukaryotic cells, used for protein synthesis and in
producing phosphoglycerides, glycerides, sphingolipids, phosphatidylserine, and …
producing phosphoglycerides, glycerides, sphingolipids, phosphatidylserine, and …
A retrospective overview of PHGDH and its inhibitors for regulating cancer metabolism
JY Zhao, KR Feng, F Wang, JW Zhang… - European journal of …, 2021 - Elsevier
Emerging evidence suggests that cancer metabolism is closely associated to the serine
biosynthesis pathway (SSP), in which glycolytic intermediate 3-phosphoglycerate is …
biosynthesis pathway (SSP), in which glycolytic intermediate 3-phosphoglycerate is …
D-3-Phosphoglycerate dehydrogenase
GA Grant - Frontiers in molecular biosciences, 2018 - frontiersin.org
l-Serine is the immediate precursor of d-serine, a major agonist of the N-methyl-d-aspartate
(NMDA) receptor. l-Serine is a pivotal amino acid since it serves as a precursor to a large …
(NMDA) receptor. l-Serine is a pivotal amino acid since it serves as a precursor to a large …
Enzymatic preparation of D-phenyllactic acid at high space-time yield with a novel phenylpyruvate reductase identified from Lactobacillus sp. CGMCC 9967
GC Xu, LL Zhang, Y Ni - Journal of biotechnology, 2016 - Elsevier
An NADH-dependent phenylpyruvate reductase (LaPPR) was identified through screening
the shotgun library of Lactobacillus sp. CGMCC 9967. It belongs to d-3-phosphoglycerate …
the shotgun library of Lactobacillus sp. CGMCC 9967. It belongs to d-3-phosphoglycerate …
Classification, substrate specificity and structural features of D-2-hydroxyacid dehydrogenases: 2HADH knowledgebase
Background The family of D-isomer specific 2-hydroxyacid dehydrogenases (2HADHs)
contains a wide range of oxidoreductases with various metabolic roles as well as …
contains a wide range of oxidoreductases with various metabolic roles as well as …
Dimerization of PHGDH via the catalytic unit is essential for its enzymatic function
Human D-3-phosphoglycerate dehydrogenase (PHGDH), a key enzyme in de novo serine
biosynthesis, is amplified in various cancers and serves as a potential target for anticancer …
biosynthesis, is amplified in various cancers and serves as a potential target for anticancer …
Efficient production of salvianic acid A from l-dihydroxyphenylalanine through a tri-enzyme cascade
Salvianic acid A (SAA), used for treating cardiovascular and cerebrovascular diseases,
possesses several pharmacological properties. However, the current methods for the …
possesses several pharmacological properties. However, the current methods for the …
Identification of Small Molecule Inhibitors Targeting Phosphoserine Phosphatase: A Novel Target for the Development of Antiamoebic Drugs
Amoebiasis, a widespread disease caused by the protozoan parasite Entamoeba histolytica,
poses challenges due to the adverse effects of existing antiamoebic drugs and rising drug …
poses challenges due to the adverse effects of existing antiamoebic drugs and rising drug …
N-terminal residues are crucial for quaternary structure and active site conformation for the phosphoserine aminotransferase from enteric human parasite E. histolytica
Phosphoserine aminotransferase (PSAT) is a pyridoxal-5′ phosphate (PLP)-dependent
enzyme that catalyzes the second reversible step in the phosphoserine biosynthetic …
enzyme that catalyzes the second reversible step in the phosphoserine biosynthetic …
Structural and functional characterisation of phosphoserine phosphatase, that plays critical role in the oxidative stress response in the parasite Entamoeba histolytica
Amoebiasis is a common parasitic infection in the developing world and is caused by the
protist Entameoba histolytica. The proliferation of E. histolytica and its ability to invade …
protist Entameoba histolytica. The proliferation of E. histolytica and its ability to invade …