The organic anion transporter (OAT) subfamily, which constitutes roughly half of the SLC22
(solute carrier 22) transporter family, has received a great deal of attention because of its …

Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …

Our understanding of the mechanisms behind inter‐and intra‐patient variability in drug
response is inadequate. Advances in the cytochrome P450 drug metabolizing enzyme field …

Protein expression of renal uptake and efflux transporters was quantified by quantitative
targeted proteomics using the surrogate peptide approach. Renal uptake transporters …

Abstract Organic anion transporters 1-10 (OAT1-10) and the urate transporter 1 (URAT1)
belong to the SLC22A gene family and accept a huge variety of chemically unrelated …

Transporters govern drug movement into and out of tissues, thereby playing an important
role in drug disposition in plasma and to the site of action. The molecular cloning of such …

The aim of this study was to determine whether primary human tubular cell monolayers
could provide a powerful tool with which to investigate the renal proximal tubular handling of …

Precision-cut tissue slices have been applied by many researchers because they represent
an organ mini-model that closely resembles the organ from which it is prepared, with all cell …

Probe substrates for, and inhibitors of, specific transporters are desired to evaluate
quantitatively the in vivo functions of transporters in humans. Based on published data …

Olmesartan, a novel angiotensin II AT1-receptor antagonist, is excreted into both bile and
urine, with minimal metabolism. Because olmesartan is a hydrophilic anionic compound …