The use of zebrafish (Danio rerio) as biomedical models

T Teame, Z Zhang, C Ran, H Zhang, Y Yang… - Animal …, 2019 - academic.oup.com
Implications Because of its fully sequenced genome, easy genetic manipulation, high
fecundity, external fertilization and rapid development, and nearly transparent embryo …

Modeling inflammation in zebrafish for the development of anti-inflammatory drugs

Y Xie, AH Meijer, MJM Schaaf - Frontiers in cell and developmental …, 2021 - frontiersin.org
Dysregulation of the inflammatory response in humans can lead to various inflammatory
diseases, like asthma and rheumatoid arthritis. The innate branch of the immune system …

The art of fin regeneration in zebrafish

C Pfefferli, A Jaźwińska - Regeneration, 2015 - Wiley Online Library
The zebrafish fin provides a valuable model to study the epimorphic type of regeneration,
whereby the amputated part of the appendage is nearly perfectly replaced. To accomplish …

Zebrafish as a model of neurodevelopmental disorders

MS De Abreu, R Genario, ACVV Giacomini, KA Demin… - Neuroscience, 2020 - Elsevier
Neurodevelopmental disorders (NDDs) caused by aberrant brain growth and development
are life-long, debilitating illnesses that markedly impair the quality of life. Animal models are …

Acute-phase proteins during inflammatory reaction by bacterial infection: Fish-model

I Charlie-Silva, A Klein, JMM Gomes, EJR Prado… - Scientific reports, 2019 - nature.com
Acute-phase protein (APPs) serum levels have been studied in many human diseases, and
their components contribute to host defense during the evolution of infectious diseases by …

Zebrafish models of human skeletal disorders: embryo and adult swimming together

M Carnovali, G Banfi, M Mariotti - BioMed Research …, 2019 - Wiley Online Library
Danio rerio (zebrafish) is an elective model organism for the study of vertebrate
development because of its high degree of homology with human genes and organs …

The zebrafish, an outstanding model for biomedical research in the field of melatonin and human diseases

P Aranda-Martínez, J Fernández-Martínez… - International Journal of …, 2022 - mdpi.com
The zebrafish has become an excellent model for the study of human diseases because it
offers many advantages over other vertebrate animal models. The pineal gland, as well as …

Use of zebrafish as a model organism to study oxidative stress: a review

S Chowdhury, SK Saikia - Zebrafish, 2022 - liebertpub.com
Dioxygen is an integral part of every living organism, but its concentration varies from organ
to organ. Production of metabolites from dioxygen may result in oxidative stress. Since …

High-glucose/high-cholesterol diet in zebrafish evokes diabetic and affective pathogenesis: The role of peripheral and central inflammation, microglia and apoptosis

JJ Wang, YJ Li, K Lai, QM Zhong, KA Demin… - Progress in Neuro …, 2020 - Elsevier
Neuroinflammation and metabolic deficits contribute to the etiology of human affective
disorders, such as anxiety and depression. The zebrafish (Danio rerio) has recently …

The food preservative sodium propionate induces hyperglycaemic state and neurological disorder in zebrafish

Y Xu, S Zhang, JL Luan, ZH Fu, MZ Sun, X Zhao… - Neurotoxicology and …, 2022 - Elsevier
Propionate is an effective mould inhibitor widely used as a food preservative. In this study,
we used zebrafish to explore the adverse effects of long-term exposure to low …