Current trends and challenges in sample preparation for global metabolomics using liquid chromatography–mass spectrometry
D Vuckovic - Analytical and bioanalytical chemistry, 2012 - Springer
The choice of sample-preparation method is extremely important in metabolomic studies
because it affects both the observed metabolite content and biological interpretation of the …
because it affects both the observed metabolite content and biological interpretation of the …
Effects of pre-analytical processes on blood samples used in metabolomics studies
Every day, analytical and bio-analytical chemists make sustained efforts to improve the
sensitivity, specificity, robustness, and reproducibility of their methods. Especially in targeted …
sensitivity, specificity, robustness, and reproducibility of their methods. Especially in targeted …
[HTML][HTML] Advantages and challenges of dried blood spot analysis by mass spectrometry across the total testing process
Methods To address these aims we performed a key word search of the PubMed and
MEDLINE online databases in conjunction with individual manual searches to gather …
MEDLINE online databases in conjunction with individual manual searches to gather …
Dried blood spots: analysis and applications
PA Demirev - Analytical chemistry, 2013 - ACS Publications
This literature review highlights recent advances and challenges in applying dried blood
spots (DBS) as a cumulative technique for sample acquisition, transport, archiving, and …
spots (DBS) as a cumulative technique for sample acquisition, transport, archiving, and …
Reviewing the metabolome coverage provided by LC-MS: Focus on sample preparation and chromatography-A tutorial
M Roca, MI Alcoriza, JC Garcia-Cañaveras… - Analytica Chimica Acta, 2021 - Elsevier
Metabolomics has become an invaluable tool for both studying metabolism and biomarker
discovery. The great technical advances in analytical chemistry and bioinformatics have …
discovery. The great technical advances in analytical chemistry and bioinformatics have …
Clinical metabolomics: the new metabolic window for inborn errors of metabolism investigations in the post-genomic era
Inborn errors of metabolism (IEM) represent a group of about 500 rare genetic diseases with
an overall estimated incidence of 1/2500. The diversity of metabolic pathways involved …
an overall estimated incidence of 1/2500. The diversity of metabolic pathways involved …
Effects of long-term storage on the biobanked neonatal dried blood spot metabolome
F Ottosson, F Russo, A Abrahamsson… - Journal of the …, 2023 - ACS Publications
Over 2.5 million neonatal dried blood spots (DBS) are stored at the Danish National
Biobank. These samples offer extraordinary possibilities for metabolomics research …
Biobank. These samples offer extraordinary possibilities for metabolomics research …
A review of blood sample handling and pre‐processing for metabolomics studies
Metabolomics has been found to be applicable to a wide range of clinical studies, bringing a
new era for improving clinical diagnostics, early disease detection, therapy prediction and …
new era for improving clinical diagnostics, early disease detection, therapy prediction and …
Preanalytical processing and biobanking procedures of biological samples for metabolomics research: A white paper, community perspective (for “Precision medicine …
BACKGROUND The metabolome of any given biological system contains a diverse range of
low molecular weight molecules (metabolites), whose abundances can be affected by the …
low molecular weight molecules (metabolites), whose abundances can be affected by the …
Investigation of the 12-month stability of dried blood and urine spots applying untargeted UHPLC-MS metabolomic assays
The use of dried blood spot (DBS) and dried urine spot (DUS) samples represents an
attractive opportunity for researchers in biomedical metabolomics to collect whole blood and …
attractive opportunity for researchers in biomedical metabolomics to collect whole blood and …